1990年至2019年间中国先天性出生缺陷的负担:一项观察性研究
Yajun Zhao1, Haonan Zhang1, Minghui Peng2
1Department of General Practice, Zhongshan Hospital, Fudan University, Shanghai, China.
Frontiers in pediatrics
|May 30, 2023
概括
中国的先天性出生缺陷 (CBD) 负担从1990年至2019年增加,发病率上升但死亡率下降. 加强产前查和预防对于解决这一公共卫生问题至关重要.
科学领域:
- 公共卫生 公共卫生
- 流行病学 流行病学
- 遗传学 是一个遗传学.
背景情况:
- 先天性出生缺陷 (CBDs) 是一个重大的全球公共卫生挑战.
- 了解CBD的流行病学趋势对于有效的公共卫生干预至关重要.
研究的目的:
- 分析1990年至2019年中国先天性出生缺陷 (CBD) 负担的趋势.
- 提供与CBD相关的发病率,死亡率和残疾调整寿命年 (DALYs) 的见解.
主要方法:
- 利用了来自2019年全球疾病负担研究 (GBD 2019) 对中国的数据.
- 用发病率,死亡率和DALY率的年平均百分比变化 (AAPC) 分析了趋势.
- 按地区,年龄,性别和CBD类型分层数据,包括先天性心脏异常.
主要成果:
- 在中国,CBD的年龄标准化发病率每年增加0.26% (1990-2019).
- 在研究期间,CBD的年龄标准化死亡率和DALYs率显著下降.
- 先天性心脏异常是CBD发病率和死亡率的主要原因.
结论:
- 与CBD相关的发病率在中国上升,受两个孩子政策等因素的影响.
- 尽管死亡率下降,但增加的发病率凸显了改善产前查和预防策略的必要性.
- 中国的CBD负担在全球排名很高,需要采取有针对性的公共卫生行动.
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