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Mycobacterium tuberculosisCitA的活性是通过囊氧化和酸盐结合调节的

Rasangi Pathirage1, Lorenza Favrot2, Cecile Petit2

  • 1Department of Pharmaceutical Sciences, University of Nebraska Medical Center Omaha NE 68198 USA don.ronning@unmc.edu.

RSC medicinal chemistry
|May 30, 2023
PubMed
概括

结核菌MycobacteriumCitA,一种药物点,是由酸盐调节的,而不是NADH. 对C143的共价修饰使CITA失活,这表明了新的结核病药物策略.

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