流行病学和与肺外结核相关的因素,在一个低流行率地区
M Rolo1, B González-Blanco1, C A Reyes1
1Department of Clinical Microbiology and Parasitology, Hospital Universitario 12 de Octubre, Madrid, Spain.
概括
全球肺外结核病例正在上升. 妇女,老年人和以前有结核病史的人有更高的风险患这种形式的疾病.
科学领域:
- 全球健康 全球健康
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 结核病 (TB) 仍然是一个重大的全球健康问题.
- 肺外结核 (EPTB) 在全球结核病例中占比越来越高.
- 关于与EPTB相关的流行病学,临床和微生物学因素的数据有限.
研究的目的:
- 研究肺外结核病的流行病学,临床和微生物学的因素.
- 确定与EPTB发展相关的风险因素.
主要方法:
- 对2016年至2021年间诊断的结核病病例进行了一项回顾性观察性研究.
- 病例被分为肺结核和肺外结核.
- 用单变量和多变量逻辑回归模型来确定EPTB风险因素.
主要成果:
- EPTB占总病例的20.9%,呈现出从2016年的22.6%到2021年的27.9%的增长趋势.
- 淋巴结核和肺结核是最常见的EPTB形式 (分别为50.6%和24.1%).
- 女性 (aOR2.46),老年患者 (≥65岁) (aOR2.47),以及有过结核病史的人 (aOR4.99) 患EPTB的可能性明显更高.
结论:
- 在研究期间,EPTB的发病率有所增加,2021年结核病总体病例显著下降,可能与COVID-19有关.
- 在这种情况下,妇女,老年人和有结核病史的个人被确定为EPTB的主要风险组.
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