肌肉内治疗与静脉内治疗的状态:一个系统的审查
Sarah S Aldharman1, Faisal T Alayed2, Fay A Almutairi3
1College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, SAU.
Cureus
|May 30, 2023
概括
肌肉内注射的米达佐拉姆提供了较快的止和较低的入院率,与静脉注射的相比,用于状态,具有类似的安全性. 这表明肌肉内注射是治疗这种神经紧急情况的可行替代方案.
科学领域:
- 神经学 神经学
- 紧急医疗 紧急医疗
- 药理学 药理学是指药理学的学科.
背景情况:
- 状态是一种关键的神经紧急情况,具有显著的发病率和死亡率.
- 有效及时的治疗对于预防致命结果至关重要.
研究的目的:
- 为了比较肌肉内和静脉内给药药物治疗 status epilepticus 的疗效和安全性.
- 评估关键结果,包括发作停止的时间,患者入院率,发作复发率和安全性.
主要方法:
- 在主要数据库 (Scopus,PubMed,Embase,Web of Science) 进行了系统的文献搜索,截至2023年3月.
- 包括直接或间接比较肌肉内和静脉内治疗状态的研究.
- 分析了五项研究,包括四项随机对照试验和一项回顾性队列研究.
主要成果:
- 肌肉内注射的米达佐拉姆与静脉内注射的迪亚泽巴姆相比,显示了停发作的时间显著缩短 (7.8分钟对11.2分钟,p=0.047).
- 在肌内治疗组中,需要入院的患者较少 (p=0.01),ICU或住院时间没有显著差异.
- 肌肉内注射组显示出较少发作复发的趋势和可比的安全结果.
结论:
- 肌肉内治疗 status epilepticus 与静脉内治疗一样有效和安全.
- 药物的可用性,药物管理后勤,成本和表单状况等因素应指导药物管理途径的选择.
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