癌症患者的肠虫感染:一个病例系列
Nathan Einhorn1, Isis Lamphier2, Olga Klinkova3
1Infectious Diseases, University of South Florida Morsani College of Medicine, Tampa, USA.
Cureus
|May 30, 2023
概括
机会性寄生虫感染,如Cryptosporidium和Cyclospora通常会影响免疫抑制的个体,导致严重的胃肠道疾病. 治疗显示出临床反应,尽管需要进一步研究以确定最佳的治疗策略.
科学领域:
- 医学寄生虫学 医学寄生虫学
- 传染性疾病 传染性疾病
- 免疫受损宿主研究
背景情况:
- 菌原生动物和微型菌是机会性病原体,会引起胃肠道感染,特别是在免疫抑制的个体中.
- 这些感染导致分泌性腹和吸收不良,在免疫功能低下的患者中出现长期和严重的症状.
- 对于这些寄生虫感染在免疫受损人群中存在有限的治疗选择.
研究的目的:
- 描述菌体和微菌体胃肠道感染的病程.
- 在免疫抑制患者中评估这些感染的治疗疗效.
- 识别常见的病原体和治疗结果.
主要方法:
- 从2012年1月到2022年6月进行了单一中心的回顾性图表审查.
- 通过使用电子健康记录,收集了被诊断患有菌或微型菌感染的患者的数据.
- 进行了描述性分析,以分析患者的人口统计,症状和治疗反应.
主要成果:
- 最常检测到的感染是Cryptosporidium (17名患者) 和Cyclospora (4名患者);没有发现Cystoisospora或microsporidian感染.
- 腹,疲劳和恶心是两个感染群体中最常见的症状.
- 尼塔佐克桑胺是Cryptosporidium的主要治疗方法,而三甲-硫甲醇或西普罗夫洛克萨则用于Cyclospora,分别有88%和75%的症状消失.
结论:
- 密体和环体是研究免疫抑制群体寄生虫胃肠道感染的重要原因.
- 尽管免疫抑制,观察到对抗寄生虫治疗的临床反应.
- 需要进一步进行随机对照试验,以充分阐明这些感染的各种治疗策略的有效性.
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