孕前孕期的孕产妇肥胖和妊娠期糖尿病对不良围产期结果的影响
Leonardo Souza de Carvalho1, Antônia Aparecida Deluca de Oliveira2, Tassiana Cristina Martins Grabovski2
1Programa de Mestrado em Saúde e Meio Ambiente, Universidade da Região de Joinville (Univille), Joinville, SC, Brasil, leocarvalho.sc@gmail.com.
怀孕前的肥胖和妊娠期糖尿病 (GDM) 独立地增加了不良围产期结果的风险. 结合起来,这些情况会显著恶化母亲和孩子的预后.
科学领域:
- 孕产妇和胎儿医学 孕产妇和胎儿医学
- 公共卫生 公共卫生
- 内分泌学 在内分泌学.
背景情况:
- 预先存在的肥胖和妊娠期糖尿病 (GDM) 是重大的公共卫生问题.
- 了解它们对围产期结果的个人和综合影响对于风险分层和干预至关重要.
研究的目的:
- 评估孤立和相关的妊娠前肥胖和GDM对不良周产期结局的影响.
- 为了比较与孤立的肥胖,孤立的GDM和两种条件的组合相关的风险.
主要方法:
- 进行了一项横截面观察研究,对1618名在巴西妇产院分娩的妇女进行了观察.
- 参与者被分为四组:没有肥胖/没有GDM (参考),孤立的GDM,孤立的肥胖 (BMI ≥30 kg/m2),和肥胖的GDM.
- 分析的不良结局包括先兆子 (PE),剖腹产 (CS),代孕年龄大 (LGA) 新生儿和新生儿重症监护室 (NICU) 的入院,并计算了调整后的几率比率 (OR).
主要成果:
- 孤立的肥胖与更高的孕前风险相关 (OR = 2.16).
- 隔离的GDM增加了剖腹产的可能性 (OR = 1.736) 和新生病重症监护室的入院 (OR = 2.32).
- 肥胖和GDM的组合增加了孕前 (OR = 1.93),剖腹产 (OR = 1.925),以及LGA新生儿 (OR = 1.81) 的风险.
结论:
- 无论是怀孕前的肥胖和GDM都独立地提高了不良周产期结果的风险.
- 肥胖和GDM的同时出现显着加剧了这些负面结果,表明了复合风险.
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