从概念到交付:一种基于酵母表达的重组蛋白质的COVID-19疫苗技术,适合全球访问
Peter J Hotez1,2, Rakesh Adhikari1, Wen-Hsiang Chen1
1Texas Children's Hospital Center for Vaccine Development, Department of Pediatrics, National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, USA.
Expert review of vaccines
|May 30, 2023
概括
针对COVID-19的一种基于酵母的新型疫苗技术是与低收入和中等收入国家 (LMIC) 生产商共同开发的. 这种重组蛋白质疫苗为流行病准备提供了一个可扩展的,全球可访问的解决方案.
科学领域:
- 生物技术是生物技术.
- 疫苗学 疫苗学 疫苗学
- 蛋白质工程是指蛋白质工程.
背景情况:
- 随着COVID-19的爆发,人们越来越需要可访问的疫苗技术.
- 现有的疫苗开发模式往往不包括低收入和中等收入国家 (LMIC) 的生产者.
- 一个可扩展的,基于酵母的重组蛋白质疫苗平台对于全球卫生安全至关重要.
研究的目的:
- 描述用于SARS-CoV-2的酵母表达重组蛋白疫苗技术的开发.
- 为了证明针对尖蛋白受体结合域 (RBD) 的疫苗的概念验证.
- 建立一个与LMIC疫苗制造商共同开发和技术转让的模型.
主要方法:
- 对于酵母表达SARS-CoV-2 RBD抗原的基因工程策略.
- 开发一个可扩展,坚固和可重复的生产过程.
- 临床前配方和评估策略.
- 技术转让协议和与LMIC生产商的合作伙伴模式.
主要成果:
- 成功开发了一种酵母衍生的复合SARS-CoV-2 RBD抗原.
- 建立适合LMIC设置的可扩展制造工艺.
- 为全球疫苗接种提供可行的技术转让模式的演示.
结论:
- 一种基于酵母的重组蛋白疫苗技术可以有效地与LMIC生产商共同开发.
- 这种方法为生产针对新兴传染病的疫苗提供了一个可持续的模型.
- 从学术机构向LMIC生产商直接转让技术,绕过了传统的跨国制药公司参与.
关键词:
科尔贝瓦克斯 (Corbevax) 是一种在 COVID-19 疫情中,印多瓦克 (INDOVAC) 是一个这就是SARSSARS.这就是SARS-CoV-2病毒.微生物发酵微生物发酵重组蛋白质蛋白质的重组蛋白质是什么?疫苗 疫苗 疫苗 疫苗更多相关视频
12:53Cell-Free Scaled Production and Adjuvant Addition to a Recombinant Major Outer Membrane Protein from Chlamydia muridarum for Vaccine Development
Published on: March 16, 2022
1.8K
08:27Synthesis and Characterization of mRNA-Loaded PolyBeta Aminoesters Nanoparticles for Vaccination Purposes
Published on: August 13, 2021
4.6K
相关概念视频
01:20The Central Dogma
23.0K
The central dogma explains the flow of genetic information from DNA nucleotides to the amino acid sequence of proteins.
RNA is the Missing Link Between DNA and Proteins
In the early 1900s, scientists discovered that DNA stores all the information needed for cellular functions and that proteins perform most of these functions. However, the mechanisms of converting genetic information into functional proteins remained unknown for many years. Initially, it was believed that a single gene is...
RNA is the Missing Link Between DNA and Proteins
In the early 1900s, scientists discovered that DNA stores all the information needed for cellular functions and that proteins perform most of these functions. However, the mechanisms of converting genetic information into functional proteins remained unknown for many years. Initially, it was believed that a single gene is...
23.0K
01:29Microorganisms in Medicine and Therapeutics
74
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
74
01:09Recombinant DNA
96.0K
Overview
96.0K
01:28Yeast Signaling
14.7K
Yeasts are single-celled organisms, but unlike bacteria, they are eukaryotes (cells with a nucleus). Cell signaling in yeast is similar to signaling in other eukaryotic cells. A ligand, such as a protein or a small molecule released from a yeast cell, attaches to a receptor on the cell surface. The binding stimulates second-messenger kinases to activate or inactivate transcription factors that further regulate gene expression. Many of the yeast intracellular signaling cascades have similar...
14.7K