在JNK/AP-1和JAK/STAT之间的相互抑制在组织再生过程中分层衰老和增殖细胞行为
Janhvi Jaiswal1,2, Janine Egert3, Raphael Engesser4
1Hilde-Mangold-Haus, University of Freiburg, Freiburg, Germany.
PLoS biology
|May 30, 2023
概括
组织修复涉及压力通路,如JNK/AP-1和JAK/STAT. 这项研究揭示了它们的空间分离是再生的关键,防止细胞亡,帮助伤口愈合和癌症研究.
科学领域:
- 细胞生物学 细胞生物学
- 发育生物学是发展生物学.
- 信号通道的信号通道.
背景情况:
- 皮质修复需要协调的压力信号通路.
- 这些通路的放松调节有助于慢性伤口和癌症.
- 了解空间信号模式对于组织修复机制至关重要.
研究的目的:
- 研究信号通路的空间模式,并在组织损伤期间修复行为.
- 阐明Drosophila影像盘中JNK/AP-1和JAK/STAT信号之间的调节网络.
- 确定对组织修复,慢性伤口病理和瘤微环境的影响.
主要方法:
- 在Drosophila影像盘中利用了TNF-α/Eiger介导的炎症损伤.
- 分析了JNK/AP-1和JAK/STAT信号通路的激活和空间分布.
- 采用数学建模来理解监管网络动态.
- 检查了RasV12中的信号模式,笔记本瘤.
主要成果:
- 艾格尔诱导的JNK/AP-1信号停止了扩散,并激活了伤口中心的衰老.
- JNK/AP-1信号细胞通过产生线粒发生因子连接体,充当膜组织者.
- 细胞自主抑制将JNK/AP-1和JAK/STAT信号分隔成不同的空间域.
- 这种空间分层对于适当的组织修复至关重要,防止过度的亡.
结论:
- 一个新的监管网络与JNK/AP-1和JAK/STAT信号之间的相互抑制空间分离细胞任务.
- 这些通路的双形分离驱动着明显的衰老和增殖行为.
- 这种机制对于组织修复至关重要,并且与慢性伤口和瘤生物学有关.
相关概念视频
The JAK-STAT Signaling Pathway
9.0K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...
9.0K
Interactions Between Signaling Pathways
6.3K
Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
6.3K
MAPK Signaling Cascades
5.7K
Mitogen-activated protein kinase, or MAPK pathway, activates three sequential kinases to regulate cellular responses such as proliferation, differentiation, survival, and apoptosis. The canonical MAPK pathway starts with a mitogen or growth factor binding to an RTK. The activated RTKs stimulate Ras, which recruits Raf or MAP3 Kinase (MAPKKK), the first kinase of the MAPK signaling cascade. Raf further phosphorylates and activates MEK or MAP2 Kinases (MAPKK), which in turn phosphorylates MAP...
5.7K
TGF - β Signaling Pathway
7.5K
The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors...
7.5K
Mitogens and the Cell Cycle
6.6K
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
6.6K
NF-κB-dependent Signaling Pathway
7.5K
The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The...
NF-κB-dependent Signaling Mechanism
The...
7.5K


