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Updated: Jul 28, 2025

Real-time Monitoring of Mitochondrial Respiration in Cytokine-differentiated Human Primary T Cells
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Real-time Monitoring of Mitochondrial Respiration in Cytokine-differentiated Human Primary T Cells

Published on: October 19, 2021

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免疫遗传代谢学揭示了调节CAR T细胞代谢和功能的关键酶

Paul Renauer1,2,3,4,5, Jonathan J Park1,2,3,5,6, Meizhu Bai1,2,3

  • 1Department of Genetics, Yale University School of Medicine, New Haven, Connecticut.

Cancer immunology research
|May 30, 2023
PubMed
概括

通过过度表达ADA或PDK1来对T细胞进行基因重编程,可以提高它们杀死癌细胞的能力. 这种代谢工程提高了CAR T细胞治疗对瘤的有效性.

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