饮食酒精消费通过产生细胞氧化应激引起角膜毒性
Anita K Ghosh1,2, Robertas Čėsna3,4, Donatas Neverauskas3,4
1Graduate Program in Biochemistry and Molecular Biology, Health Sciences Division, Loyola University Chicago, Maywood, Illinois, USA.
概括
饮酒会引起眼睛的毒性,导致干眼疾病的症状. 这项研究表明,酒精会损害角膜上皮细胞,并增加小鼠的氧化应激,证实了临床观察.
科学领域:
- 眼科医生 眼科 眼科
- 毒理学 毒理学 毒理学
- 细胞生物学 细胞生物学
背景情况:
- 临床研究将酒精使用与干眼疾病联系起来.
- 关于酒精对眼睛有毒性的临床前数据有限.
研究的目的:
- 研究酒精对眼睛表面的影响.
- 在体外和体内检查酒精诱导的眼睛毒性.
主要方法:
- 人类角膜上皮细胞 (HCE-T) 暴露于乙醇.
- 给小鼠饮含有酒精的液体饮食10天.
- 评估了眼睛表面损伤,角膜厚度和基因表达.
主要成果:
- 乙醇增加了角膜细胞中的氧化应激和NFκB信号传递.
- 酒精饮食显著增加了角膜损伤 (光素染色).
- 在酒小鼠中观察到角膜厚度降低和信号通路失调.
结论:
- 暴露于酒精会诱导小鼠的眼睛毒性.
- 这些发现与临床数据一致,该数据将酒精消费与眼睛表面疾病联系在一起.
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