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在不孕症中抗β2-糖蛋白I/HLA-DR抗体

Yosuke Ono¹, Shinichiro Wada², Hajime Ota²

¹Department of Obstetrics and Gynecology, University of Yamanashi, 1110 Shimokawahigashi, Chuo City, Yamanashi Prefecture 409-3898, Japan; Department of Obstetrics and Gynecology, Teine Keijinkai Hospital, 1-40, 12-chome, Maeda, Teine-ku, Sapporo-shi 006-8555, Japan.

Journal of reproductive immunology

|May 30, 2023

概括

抗β2-糖蛋白I/HLA-DR (抗β2GPI/HLA-DR) 抗体与接受辅助生殖技术 (ART) 的女性的不孕症,子宫内膜异位症和复发性植入失败 (RIF) 有关. 这种抗体可能是治疗不孕症的治疗点.

科学领域:

生殖免疫学生殖免疫学
在不孕症中的自身免疫性.

背景情况:

不孕症影响人口的很大一部分,自身免疫因素可能发挥作用.
抗β2-糖蛋白I/HLA-DR (抗β2GPI/HLA-DR) 抗体与各种自身免疫性疾病有关.

研究的目的:

调查抗β2GPI/HLA-DR抗体与不孕症的病理生理学之间的关联.
探索抗β2GPI/HLA-DR抗体在不孕妇女中的患病率及其与子宫内膜异位症和复发性植入失败 (RIF) 的相关性.

主要方法:

一项前性研究涉及224名患有不孕症的女性.
测量了抗β2GPI/HLA-DR抗体的血清水平.
在抗体阳性和抗体阴性组之间比较了临床因素,包括接受辅助生殖技术 (ART) 的女性的子宫内膜异位症和RIF.

主要成果:

对抗β2GPI/HLA-DR抗体的阳性在17.9%的不育妇女中被观察到.
具有抗体的女性显示出子宫内膜异位症的患病率更高 (32.5%与17.4%,P=0.048).
在接受ART的女性中,抗β2GPI/HLA-DR抗体阳性与较高的RIF患病率相关 (43.5%对20.8%,P=0.032).

结论:

抗β2GPI/HLA-DR抗体阳性与不孕妇女的子宫内膜异位症有关.
该抗体还与在接受ART的妇女中反复发生的植入失败有关.
抗β2GPI/HLA-DR抗体可能有助于不孕症病理生理学,并代表潜在的治疗标.

关键词:

针对β2-糖蛋白I/HLA-DR复合物的自身抗体子宫内膜异位症是什么?子宫内膜异位症是什么不孕不育不孕不育不孕不育经常发生的植入失败.

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