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心理灵活性取决于广泛分布的白质网络:基于连接体的病变-症状映射的因果证据

Marco Anziano¹, Michael Mouthon¹, Harriet Thoeny²

¹Laboratory for Neurorehabilitation Science, Medicine Section, Faculty of Science and Medicine, University of Fribourg, Fribourg, Switzerland.

Cortex; a journal devoted to the study of the nervous system and behavior

|May 30, 2023

概括

保持心理灵活性 (MF) 取决于白质的完整性. 对特定大脑连接的损伤会损害切换任务的能力,这凸显了结构性大脑网络对认知功能的重要性.

科学领域:

神经科学是一个神经科学.
认知神经学认知神经学
神经成像是一种神经成像.

背景情况:

心理灵活性 (MF) 对于任务切换至关重要,并依赖于相互连接的大脑区域.
假设连接这些区域的白质轨道的完整性对于维持MF至关重要.

研究的目的:

调查白质完整性与精神灵活性之间的因果关系.
绘制白质病变对大脑结构连接体的影响及其与MF表现的关联.

主要方法:

使用基于连接体的病变症状映射方法.
评估了167名第一次单边中风的患者,使用Trail Making Test,测量MF.
分析了白质病变位置和MF赤字之间的关联.

主要成果:

货币的赤字与左侧面的前--和半球间连接的损伤有关.
左皮质 - 基底和皮质 - 柱状连接的损伤也与受损的MF相关.
认知控制,默认模式和注意力网络中的白质脱节与减少的MF有关.

结论:

白质的完整性在保持心理灵活性方面发挥着核心作用.
提供了MF所涉及的皮层和皮下结构之间功能相互依赖的因果关系证据.
强调了连接学在病变症状映射中的必要性,以了解更高阶的认知功能.

关键词:

大脑损伤脑损伤基于连接组的病变症状映射.心理灵活性精神灵活性步道制作试验试验步道制作试验白质是白质的组成部分.

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