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带有光扩散纤维的体外膜氧化器用于治疗一氧化碳中毒:用单元细胞进行实验,数学建模和性能评估
James Childs1, Anna Fischbach2,3, Artur Smirnov1
1Department of R&D, IPG Medical, Marlborough, Massachusetts, USA.
Lasers in surgery and medicine
|May 30, 2023
概括
这项研究表明,一种新的光外体静脉膜氧化器 (p-ECMO) 装置可以显著加快从血液中去除一氧化碳 (CO). 该设备与氧气疗法相结合,显示了减少CO中毒治疗时间的潜力.
科学领域:
- 生物医学工程 生物医学工程
- 毒理学 毒理学 毒理学
- 医疗器械 医疗器械
背景情况:
- 一氧化碳 (CO) 中毒每年导致美国约5万名紧急访问.
- 氧化碳对血红蛋白的高度亲和力会导致组织缺氧.
- 高压氧 (HBO) 是有效的,但可访问性有限.
研究的目的:
- 通过使用具有不同激光波长的新型光外体静脉膜氧化器 (p-ECMO) 来评估CO消除率.
- 开发一个数学模型来预测p-ECMO设备中的二氧化碳消除.
主要方法:
- 在体外实验中使用单细胞p-ECMO设备,使用635nm或465nm激光器进行实验.
- 评估了不同激光功率和设备配置的碳氧血红蛋白 (COHb) 降低.
- 开发了一个数学模型,整合了流体动力学,光分布和血红蛋白动力学.
主要成果:
- 随着激光功率,血液传输时间和膜表面积的增加,COHb去除率增加.
- 与单独氧疗法相比,p-ECMO装置显著减少了COHb半衰期 (例如,1.5分钟与8.5分钟相比).
- 数学模型准确地预测了实验COHb消除率.
结论:
- 开发的单细胞p-ECMO装置显示了快速降低COHb的潜力.
- 这项技术作为辅助治疗,可以显著减少CO中毒的治疗时间.
- 数学模型可以指导设计更大,更高效的p-ECMO设备.
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