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一个智能金属-多-DNAzyme纳米平台用于基因-化学动力学协同瘤治疗

Chao Xing¹, Qitian Lin², Yiting Chen³

¹Fujian Key Laboratory of Functional Marine Sensing Materials, Center for Advanced Marine Materials and Smart Sensors, College of Materials and Chemical Engineering, Minjiang University, Fuzhou 350108, China; MOE Key Laboratory for Analytical Science of Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou 350116, China.

Acta biomaterialia

|May 30, 2023

概括

一个新的纳米平台将DNAzyme基因疗法与化学动力学疗法相结合,用于增强癌症治疗. 该系统利用酸和离子进行有针对性的输送和辅因子自供,改善治疗结果.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
癌症治疗癌症治疗

背景情况:

基于DNA酶的基因调节为癌症治疗提供了希望,但在输送和辅助因子供应方面面临挑战.
现有的方法需要有效的策略来克服这些限制,以获得强大的治疗效果.

研究的目的:

开发一个智能金属-多-DNAzyme纳米平台 (TA-Mn@Dz NPs) 用于协同基因-化学动力学瘤治疗.
设计一个具有内在稳定性,有效交付和自给自足的辅助因子供应的系统,以改善癌症治疗.

主要方法:

使用酸作为结构单元构建TA-Mn@Dz NP,以组装Mn2+/DNAzyme和瘤酸响应纳米载体.
利用酸性瘤环境触发NP分解,释放DNAzyme和Mn2+进行治疗作用.
评估了纳米平台在MCF-7瘤携带小鼠中的协同抗瘤效应.

主要成果:

TA-Mn@Dz NPs证明了有效的输送和辅因子自给,增强了DNA酶基因疗法.
释放的Mn2+增强了DNA酶活性,并通过从H2O2.2.中产生细胞毒基 (·OH) 来激活化学动力学治疗 (CDT).
在体内实现了显著的协同基因化学动力学抗瘤效应,突显了该平台的治疗潜力.

结论:

开发的TA-Mn@Dz NP代表了集成基因疗法和CDT的智能纳米平台.
这种方法有效地解决了DNA酶传递和辅因子供应的挑战,为先进的癌症治疗策略铺平了道路.
该研究提供了一种简化方法,用于将基因治疗与CDT结合起来,用于双催化瘤治疗.

关键词:

化学动力学疗法是一种化学动力学疗法.这就是DNAzyme DNA酶.基因治疗是一种基因疗法.金属的辅助因素之一.聚醇是一种多的化合物.

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