动态治疗方案 (DTRs) 用于研究瘤学中的治疗序列:一个范围审查协议
Susana Esteves1,2, João Miguel Alves2, Pedro Pereira Rodrigues2
1Unidade de Investigação Clínica, Instituto Portugues de Oncologia de Lisboa Francisco Gentil EPE, Lisboa, Portugal slaesteves@gmail.com.
BMJ open
|May 30, 2023
概括
本范围审查映射了如何在瘤学临床研究中评估动态治疗方案 (DTRs). 它旨在改善针对个性化癌症治疗顺序的证据,并确定研究缺口.
科学领域:
- 在瘤学瘤学.
- 临床研究方法论 临床研究方法论
- 医疗保健服务研究 医疗服务研究
背景情况:
- 在瘤学中,最佳的治疗顺序受到不断发展的疗法和对延迟治疗效果的有限证据的挑战.
- 动态治疗方案 (DTR) 提供了一个基于患者和治疗动态的个性化治疗个性化的框架.
- 需要了解目前在临床研究中如何评估DTR,以告知决策.
研究的目的:
- 系统地绘制临床瘤学研究中DTR评估的范围和方法.
- 确定如何使用DTR来生成癌症治疗序列的临床决策证据.
- 揭示DTR瘤学研究中的知识和方法差距.
主要方法:
- 在主要数据库 (MEDLINE,Web of Science,Scopus) 和临床试验注册表中进行系统的文献搜索.
- 包括实验和观察性临床研究,使用DTR概念解决治疗顺序.
- 数据提取侧重于癌症类型,设置,治疗,定制变量,决策规则,结果和统计方法.
主要成果:
- (在审查完成后确定) 审查将总结在瘤学中进行的DTR评估类型.
- (将在审查完成后确定) 它将详细说明用于DTR评估和证据生成的方法.
- (将在审查完成后确定) 调查结果将突出显示DTR在临床瘤学中的应用现状.
结论:
- 这一范围审查将增强对瘤学中DTR评估方法的理解.
- 它将确定当前研究中的差距,指导未来关于个性化癌症治疗顺序的研究.
- 这些发现将有助于在动态的瘤治疗环境中为临床决策制定更强有力的证据.
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