在体外模型分析在连续雾化过程中高流量气溶输送的分析
Michael McPeck1, Jane Moon1, Jeyanthan Jayakumaran1
1Pulmonary, Critical Care and Sleep Medicine Division, Department of Medicine, Stony Brook University Medical Center, Stony Brook, New York.
Respiratory care
|May 30, 2023
概括
这项研究开发了一种解剖模型,通过高流量鼻连续雾化来跟踪气溶输送. 鼻腔接口造成了显著的气溶损失,在雾化器技术之间观察到差异.
科学领域:
- 呼吸系统药物 呼吸系统药物
- 生物医学工程 生物医学工程
- 药理动力学 药理动力学
背景情况:
- 了解通过连续雾化高流鼻腔管 (HFNC) 进行气溶输送对于优化呼吸治疗至关重要.
- 以前的方法缺乏精确度来量化实时气溶命运和电路损失.
- 解剖学建模提供了一个可控的环境来研究这些复杂的交付动态.
研究的目的:
- 开发和验证一个开源的解剖学模型,用于评估HFNC连续雾化过程中的气溶输送.
- 量化气溶在输送电路中的损失,特别是在鼻腔界面.
- 为了比较不同雾化器技术 (呼吸增强喷气雾化器与振动网状雾化器) 的性能,以及它们对输液速率的响应能力.
主要方法:
- 解剖模型创建:一个3D打印的头部和面部结构与鼻腔气道造,连接到一个活塞通风器.
- 质量平衡实验:盐溶液与Technetium-99m注入1小时,气溶的输送用喉下部的马流量计测量.
- 变量测试:在使用BEJN和振动网状雾化器的不同输注速率 (10-40毫升/小时) 和气体流量 (60毫升/分钟) 中评估连续雾化.
主要成果:
- 气溶流失的主要地点是鼻腔接口,约占气溶输出的25%.
- 在两种雾化器类型之间观察到电路组件沉积的显著差异.
- 虽然这两种雾化器的气溶输送量增加,输入速率更高,但BEJN的输送能力在60L/分钟的气体流量下大大提高.
结论:
- 开发的解剖学模型准确地识别了HFNC连续雾化期间的气溶损失地点.
- 这种体外系统为评估气溶输送参数提供了一个现实的平台,包括雾化器技术和输注速率.
- 实时分析可以量化多个变量对气溶输送效率的影响.
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