在高流量鼻治疗过程中增强气溶输送
Jane Moon1, Michael McPeck2, Jeyanthan Jayakumaran2
1Pulmonary, Critical Care and Sleep Medicine Division, Department of Medicine, Stony Brook University Medical Center, Stony Brook, New York. Jane.moon@stonybrookmedicine.edu.
与振动网状雾化器相比,呼吸增强喷气雾化器在高流量鼻腔管 (HFNC) 治疗期间提供了显著更多的气溶. 这项技术允许在重症患者中精确地定位喷雾剂药物剂量.
科学领域:
- 呼吸系统药物 呼吸系统药物
- 医疗器械工程 医疗器械工程
- 药理学 药理学是指药理学的学科.
背景情况:
- 通过高流量鼻腔管 (HFNC) 输送气溶液药物随着气流的增加而减少.
- 与标准设备相比,增强呼吸的喷气式雾化器 (BEN) 可能会改善气溶的输出.
研究的目的:
- 为了测试BEN在HFNC过程中增加气溶产量的假设.
- 为了比较BEN技术与振动网状雾化器 (VMN) 技术用于气溶输送.
主要方法:
- 在模拟HFNC条件下 (5-60毫升/小时盐溶液输注) 在隔离电路中测量了BEN和VMN的气溶输出.
- 药物输送在体外量化,使用3D打印的头部模型与HFNC (10-60L/分钟) 和99mTc/盐水输注.
- 气管气溶输送速率 (μg NaCl/分钟) 用一个屏蔽的流量计进行测量.
主要成果:
- 随着气体流量增加,BEN的输出量增加,最高达到50毫升/小时,而VMN的最大值为12毫升/小时.
- 在60L/分钟HFNC时,BEN提供了3.16至316.8微克NaCl/分钟,远远超过VMN的23.5至61.7微克NaCl/分钟.
- 药物输送速度取决于输注的流量和HFNC气体流量,但在特定的输注速率 (5-12毫升/小时) 独立于雾化器类型.
结论:
- 增加气体流量增加了BEN气溶的输出,证明了增强呼吸的效果.
- 在60L/分钟的HFNC中,BENs的气溶排放量高达VMNs的5倍.
- 在重症患者中,BEN技术可以通过调整输液速率来实现气溶剂药物剂量的床边定位.
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