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氧化诱导的肌肉神经病变:一个病例系列

Devan Mair^1,2, Alvar Paris^2,3, Safiya A Zaloum^1,2

¹Queen Mary University of London Barts and The London School of Medicine and Dentistry, London, UK.

Journal of neurology, neurosurgery, and psychiatry

|May 30, 2023

概括

娱乐性氧化 (N₂O) 使用可能会导致严重的神经损伤,包括骨髓神经病变. 这项研究详细介绍了119例英国病例,强调了症状和脊髓影响,以改善早期检测和治疗.

科学领域:

神经学神经学
毒理学毒理学毒理学
公共卫生公共卫生

背景情况:

氧化 (N₂O) 是英国年轻人中普遍存在的娱乐性毒品.
与N₂O使用相关的神经不良影响越来越被认可,但数据通常来自有限的病例报告.

研究的目的:

总结迄今为止最大的N₂O-骨髓质神经病症病例系列中的临床和调查发现.
提高意识,促进早期识别和治疗N₂O诱导的神经损伤.

主要方法:

对119名被诊断患有N₂O-骨髓神经病变的患者进行了回顾性分析.
从伦敦,伯明翰和曼彻斯特的NHS教学医院收集的数据.
审查了临床表现,神经学检查和MRI发现.

主要成果:

麻醉,特别是在下肢,是最常见的呈现症状 (85%).
走路无力症和膀/肠道障碍是常见的. 在大多数情况下,MRI揭示了椎脊髓干扰 (C3-C5).
每周的N₂O消费与甲基马龙酸水平升高相关,表明功能性维生素B₁₂缺乏.

结论:

娱乐性氧化滥用的神经损伤是全球日益关注的问题.
增加N₂O的可用性有助于英国骨髓炎病例的增加.
了解各种临床表现对于及时诊断和干预至关重要.

关键词:

缺少B12的原因之一是缺乏B12.临床神经学临床神经学骨髓病变是一种骨髓病变.神经病变是一种神经病变.

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