血液生成的12/15-氧基酶活性对与真菌相关的过敏喘有负面影响
Mgayya Makullah1, Diandra A Ellis1, MaryJane Jones1
1Department of Microbiology and Immunology, Tulane University, New Orleans, Louisiana, United States.
概括
免疫细胞中的12/15-lipoxygenase (12/15-LOX) 酶通过促进炎症和损害肺功能,加剧过敏真菌喘. 针对12/15-LOX可能为严重喘病例提供新的治疗策略.
科学领域:
- 免疫学 免疫学 免疫学
- 肺部病理学 肺部病理学
- 生物化学 生物化学
背景情况:
- 严重的喘经常与真菌敏感性有关,特别是对*Aspergillus fumigatus*.
- 作为5-氧基酶 (5-LOX) 的产物,白血的含量在严重喘中升高,是当前治疗的目标.
- 12/15-氧基酶 (12/15-LOX) 在喘病因发生中的作用不太清楚.
研究的目的:
- 为了研究12/15-lipoxygenase (12/15-LOX) 在实验性真菌喘中的作用.
- 为了确定血液细胞中的12/15-LOX活性是否有助于喘恶化.
主要方法:
- 在C57BL/6野生型 (WT) 和12/15-LOX缺乏 (*Alox15*-/-) 的小鼠中诱导实验性真菌喘.
- 测量呼吸道过敏反应 (AHR),肺炎,细胞因子和化学因子水平.
- 流细胞计和骨髓奇美拉研究,以评估细胞贡献.
主要成果:
- *Alox15*-/-小鼠与WT小鼠相比,肺功能得到改善,肺炎减少.
- 在*Alox15*-/-小鼠中观察到骨髓状和淋巴状细胞数量减少,以及较低的1型和2型细胞因子.
- 血衍生的12/15-LOX被确定为真菌喘中AHR的关键贡献者.
结论:
- 造血基12/15-LOX在恶化过敏真菌喘方面发挥着重要作用.
- 这种酶有助于1型和2型免疫反应,导致肺功能受损.
- 针对12/15-LOX为严重的真菌相关喘提供了潜在的治疗途径.
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