肠道神经系统作为SARS-CoV-2和其他病毒感染的目标和来源
Luisa Valdetaro1,2, Beatriz Thomasi1,3, Maria Carolina Ricciardi1
1Postgraduate Program in Neuroscience, Neurobiology Department, Federal Fluminense University, Niterói, Rio de Janeiro, Brazil.
概括
严重急性呼吸道综合征冠状病毒2 (SARS-CoV-2) 可以感染肠道神经系统 (ENS),可能引发COVID-19症状. 这篇评论探讨了SARS-CoV-2如何影响肠-大脑轴和神经炎症.
科学领域:
- 神经科学是一个神经科学.
- 胃肠病学 胃肠病学
- 病毒学 病毒学
背景情况:
- 冠状病毒疾病2019 (COVID-19) 影响多个器官系统,包括胃肠道和神经系统.
- 肠道神经系统 (ENS) 调节肠道功能,并与病毒感染和肠道功能障碍有关.
- 肠道神经系统和肠道免疫系统之间的神经免疫相互作用对健康和疾病至关重要.
研究的目的:
- 审查由SARS-CoV-2感染胃肠道和内脏系统的证据.
- 讨论与COVID-19相关的病毒机制,神经可塑性和神经炎症.
- 要突出肠道神经质网络在COVID-19病变发生过程中的作用.
主要方法:
- 文献综述侧重于胃肠道和ENS的SARS-CoV-2感染.
- 对影响神经可塑性和神经炎症的病毒诱导机制的分析.
- 在COVID-19的背景下检查肠-大脑轴.
主要成果:
- 越来越多的证据表明,SARS-CoV-2感染了ENS.
- 肠道炎症和功能障碍受到肠道神经细胞和微生物群的影响.
- 由肠道驱动的过程可能会导致COVID-19中系统性炎症和中枢神经系统病理.
结论:
- 肠道神经系统是SARS-CoV-2的潜在目标和入口点.
- 肠道神经系统的SARS-CoV-2感染可能会引发或加剧COVID-19症状.
- 肠道神经质网络在COVID-19的多方面的影响中发挥着关键作用.
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