从发作到远程缺血病调节的时间和急性中度缺血性中风后的临床结果
Yu Cui1, Yi-Ning Chen2, Thanh N Nguyen3
1Department of Neurology, General Hospital of Northern Theater Command, Shenyang, China.
Annals of neurology
|May 30, 2023
概括
在24小时内进行早期远程缺血性调节 (RIC),改善了急性中度缺血性中风患者的治疗结果,而这些患者无法接受其他治疗. 晚期RIC与常规护理相比没有显著的益处.
科学领域:
- 神经学 神经学
- 心血管医学 心血管医学
- 再生医学是一种再生医学.
背景情况:
- 急性中度缺血性中风需要及时有效的干预措施.
- 远程缺血调节 (RIC) 是一种潜在的治疗策略.
- 在中风患者中,RIC启动的最佳时间仍在调查中.
研究的目的:
- 调查急性中等性缺血性中风患者早期与晚期远程缺血性调节 (RIC) 启动和临床结果之间的关联.
- 分析开始治疗时间 (OTT) 对RIC疗效的影响.
主要方法:
- 进行了对RICAMIS试验的后期探索性分析.
- 患者被分为早期RIC (OTT ≤24小时),晚期RIC (OTT 24-48小时) 和对照组.
- 主要结局是90天后优异的功能结局,通过治疗意图和每条协议分析进行评估.
主要成果:
- 与对照组相比,早期的RIC组显示出明显高的优秀功能结果比例 (调整后的绝对差异:8.1%).
- 在RIC后期组和对照组之间没有观察到结果的显著差异.
- 早期的RIC组与晚期的RIC组相比,没有显示出统计学上显著的差异.
结论:
- 在中风发作后24小时内早期启动RIC可能与急性中度缺血性中风患者的改善临床结果有关.
- 对那些无法接受静脉输血栓溶解或内血管治疗的患者来说,RIC可能是一个可行的治疗选择.
- 需要进一步的研究来证实这些发现并优化RIC协议.
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