在帕金森病中,与部相关的功能网络的破坏
Junyan Sun1, Jinghong Ma2, Linlin Gao3
1Center for Movement Disorders, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
NPJ Parkinson's disease
|May 30, 2023
概括
休息状态的功能性MRI揭示了帕金森病 (PD) 和前性阶段的Locus coeruleus (LC) 网络中断. 这些变化与临床特征相关,区分体为先的PD与脑为先的PD.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 医疗成像医学成像
背景情况:
- 在帕金森病 (PD) 中,Locus coeruleus (LC) 受到显著影响.
- 了解PD中LC相关的静止状态网络 (RSN) 的变化对于诊断和治疗至关重要.
- 异形眼神快速运动睡眠行为障碍 (iRBD) 是包括PD在内的同核蛋白病变的前发症阶段.
研究的目的:
- 调查与LC相关的RSN中的功能连接 (FC) 变化.
- 检查这些RSN变化与iRBD的临床特征之间的关联,PD与REM睡眠行为障碍 (PDRBD+),和PD没有RBD (PDRBD-).
主要方法:
- 使用了休息状态功能性MRI (rs-fMRI).
- 分析的重点是与LC相关的RSN中的功能连接.
- 评估了RSN变化与临床数据 (认知,持续时间,抑郁,RBD严重程度) 之间的相关性.
主要成果:
- 在iRBD和PDRBD+患者中观察到与LC相关的RSN中类似地破坏了FC模式.
- 与LC相关的RSN在PDRBD-患者中的影响较小,与iRBD和PDRBD+患者相比.
- 与LC相关的RSN的FC与iRBD中的认知和持续时间相关,PD中的抑郁RBD-,PD中的认知和RBD严重程度RBD+.
结论:
- 与LC相关的RSN在α-synucleinopathies (iRBD) 和body-first PD (PDRBD+) 的前阶段被显著破坏.
- 这些干扰在脑第一PD (PDRBD-) 中不那么明显.
- 在这些疾病中,RSN的变化与明显的临床特征有关,突出了潜在的生物标志物.
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