长非编码RNA KCND1通过向YBX1来保护心脏免受缩
Rui Yang1,2,3, Liangliang Li2, Yumeng Hou2
1Shanghai Frontiers Science Research Center for Druggability of Cardiovascular noncoding RNA, Institute for Frontier Medical Technology, Shanghai University of Engineering Science, Shanghai, 201620, China.
Cell death & disease
|May 30, 2023
概括
长非编码RNA KCND1 (LncKCND1) 通过调节线粒体功能和下游目标YBX1.1,保护心脏缩. 这一发现为心脏病提供了潜在的治疗策略.
科学领域:
- 心血管生物学 心血管生物学
- 分子心脏病学分子心脏病学
- 非编码RNA研究研究
背景情况:
- 心脏缩是心血管疾病中显著的结构变化.
- 长非编码RNAs (LncRNAs) 在心脏缩中起着至关重要的作用.
- 了解LncRNAs在心脏重塑中的特定作用是必不可少的.
研究的目的:
- 研究LncRNA KCND1 (LncKCND1) 在心脏缩中的作用.
- 阐明LncKCND1在心脏中的功能背后的分子机制.
- 评估LncKCND1作为病理性心脏缩的潜在治疗标.
主要方法:
- 在小鼠和心肌细胞中利用横向大动脉收缩 (TAC) 和血管素II (Ang II) 模型.
- 对LncKCND1和YBX1.1进行了淘汰和过度表达的研究.
- 使用质谱和RNA免疫沉 (RIP) 测试来确定直接相互作用.
- 评估心脏线粒体功能和心肌细胞缩.
主要成果:
- 在心脏缩模型中,LncKCND1的下调.
- 过度表达LncKCND1可以防止过度缩,改善心脏功能和增强线粒体功能.
- LncKCND1直接与下游目标YBX1结合并进行上调.
- YBX1还表现出对高的保护作用.
结论:
- LncKCND1对病理性心脏缩起着保护作用.
- LncKCND1-YBX1轴是心脏缩和线粒体功能的一个关键调节器.
- LncKCND1代表了治疗心脏缩的一个有前途的治疗标.
相关概念视频
02:39lncRNA - Long Non-coding RNAs
8.7K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.7K
01:31Regulation of Heart Rates
1.9K
The regulation of heart rate is a complex process controlled by the autonomic nervous system (ANS), hormonal influences, and intrinsic cardiac mechanisms. The ANS has two main components: the sympathetic nervous system (SNS) and the parasympathetic nervous system (PNS).
The SNS increases heart rate through the release of norepinephrine and epinephrine, which act on beta-1 adrenergic receptors in the heart. This action increases the rate of depolarization in the sinoatrial (SA) node, the heart's...
The SNS increases heart rate through the release of norepinephrine and epinephrine, which act on beta-1 adrenergic receptors in the heart. This action increases the rate of depolarization in the sinoatrial (SA) node, the heart's...
1.9K
01:29Cardiomyopathy III: Hypertrophic Cardiomyopathy
17
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
17
01:29Cardiomyopathy IV: Restrictive Cardiomyopathy
12
Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
12
01:30Cardiomyopathy II: Dilated Cardiomyopathy
12
Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
12
01:13Formation of Muscle Fibers from Myoblasts
5.0K
De novo myogenesis, or the formation of muscle fibers, begins during the early embryonic stages. The skeletal muscle is formed from somites– blocks of embryonic cell layers. The somites are further divided into dermatomes, myotomes, sclerotomes, and syndetomes. Among these, the myotomes give rise to muscle fibers.
Muscle progenitor cells (MPCs) are formed from the myotomes. MPCs express genes that encode the transcription factors Pax3 and Pax7. Along with Pax 3/7, other transcription...
Muscle progenitor cells (MPCs) are formed from the myotomes. MPCs express genes that encode the transcription factors Pax3 and Pax7. Along with Pax 3/7, other transcription...
5.0K