在阻塞性睡眠呼吸暂停中,上升的网状激活系统的功能连接性发生变化
Jung-Ick Byun1, Geon-Ho Jahng2, Chang-Woo Ryu2
1Department of Neurology, Kyung Hee University College of Medicine, Kyung Hee University Hospital at Gangdong, Seoul, 05278, Republic of Korea.
阻塞性睡眠呼吸暂停 (OSA) 改变了上升网络激活系统 (ARAS) 中的大脑连接. 特定的ARAS核在OSA患者中显示出不同的功能连接性 (FC),与疾病严重程度有关.
科学领域:
- 神经科学是一个神经科学.
- 睡眠医学 睡眠医学
- 医疗成像医学成像
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 的特点是睡眠期间重复唤醒.
- 这些唤醒可能会破坏上升的网状激活系统 (ARAS) 的功能连接 (FC),这对于保持清醒至关重要.
研究的目的:
- 研究ARAS内静止状态FC的变化及其与中度至重度OSA患者皮层和皮下区域的连接.
- 探索ARAS-皮质FC和OSA严重程度之间的关系.
主要方法:
- 使用休息状态功能磁共振成像 (fMRI) 和夜间多睡眠学.
- 在50名OSA患者和20名健康对照中,比较了8个ARAS核和105个皮层/皮下区域之间的FC.
- 采用了以ARAS-皮质FC为重点的种子-囊分析.
主要成果:
- 在三种ARAS核中观察到FC的显著差异:coeruleus位置 (LC),后背体核 (LDTg) 和腹体区域 (VTA).
- 在OSA患者中,LC-precuneus,LC-posterior cingulate gyrus和LC-right lateral occipital cortex (LOC) FC表现得更强烈.
- 在OSA患者中,LDTg右侧的LOC FC增加和VTA右侧的LOC FC减少.
- 平均LC皮层FC与兴奋,呼吸暂停和呼吸暂停-呼吸暂停指数正相关.
结论:
- 静止状态的ARAS-皮质FC在中度至重度OSA患者中发生变化.
- 观察到的变化,特别是在源自LC的诺亚上腺素路径中,与OSA严重程度和兴奋水平有关.
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