二级运动皮质 - 条形体电路有助于抑制感知决策行为中的不适当反应
Jing Liu1,2, Dechen Liu1, Xiaotian Pu1,2
1Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, 200031, China.
二级运动皮层 (M2) 通往背状条体 (DS) 的路径对于在决策过程中抑制不正确的行为至关重要. 这项研究澄清了M2的情况.
科学领域:
- 神经科学是一个神经科学.
- 认知神经科学 认知神经科学
- 行为神经科学 行为神经科学
背景情况:
- 二级运动皮层 (M2) 参与与选择相关的信息和指导行动.
- 背上条纹体 (DS) 也在决策中发挥着作用.
- 在感知决策中DS信号的M2调制的确切作用仍然不清楚.
研究的目的:
- 调查M2如何影响DS信号以影响感知决策.
- 阐明M2-to-DS途径在抑制不适当反应中的功能.
主要方法:
- 鼠标执行了一个视觉上的Go/No-Go任务.
- 执行了M2投射到DS的失活.
- 在M2和DS中记录了神经活动.
- 直接和间接途径条状神经元的反应被测量和操纵.
主要成果:
- 在Go/No-Go任务中,将M2投射到DS无效化增加了错误报警率.
- M2神经元选择信号与行为表现相关.
- 禁用M2投影减少了DS中的选择信号.
- 间接途径条状神经元对No-Go刺激的早期反应至关重要;不激活它们会增加错误警报.
结论:
- 在感知决策过程中,M2到DS路径对于抑制不适当的反应至关重要.
- 这一途径会影响背上条纹体内的选择信号.
- 在M2介导的决策过程中,直接和间接的条状通路的具体作用被确定.
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