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抗生素选择B组链球菌预防在母亲报告的青素过敏和相关的新生儿结局的母亲
Josephine B Snider1, Leena B Mithal2, Jason H Kwah3
1Department of Pediatrics, Division of Hospital-Based Medicine, Ann and Robert H. Lurie Children's Hospital of Chicago and Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
BMC pregnancy and childbirth
|May 30, 2023
概括
患有青素过敏的孕妇更频繁地接受替代抗生素,以预防B组链球菌 (GBS). 这增加了新生儿产后实验室抽取量,影响了婴儿护理.
科学领域:
- 产科和妇科 产科和妇科
- 新生儿医学 新生儿医学
- 传染性疾病 传染性疾病
背景情况:
- 在分娩期间预防B组链球菌 (GBS) 预防对于预防新生儿感染至关重要.
- 青素是GBS预防的首选抗生素,但过敏需要替代药物.
- 了解替代抗生素选择对新生儿结局的影响对于临床实践很重要.
研究的目的:
- 为了比较抗生素选择的产后GBS预防在怀孕的个体和没有青素过敏.
- 调查GBS预防的抗生素选择是否与新生儿结局的差异有关.
主要方法:
- 在一个大规模的城市医院对母婴双 (2005-2018) 的回顾性队列研究.
- 在有或没有记录的青素过敏的母亲之间比较抗生素预防 (β-乳糖与替代品).
- 分析了新生儿结局,包括产后血液抽取,抗生素给药,新生儿重症监护室入院,细菌血症和住院时间.
主要成果:
- 10.3%的母亲报告说他们对青素过敏,而且接受替代GBS预防的可能性显著增加 (73.7%对比0.2%).
- 接受替代预防药物 (万科米辛或克林达米辛) 的母亲的新生儿患产后抽血的可能性更高 (20.8%与17.3%,或1.25).
- 在多变量调整 (aOR 1.23) 后,替代预防和增加产后实验室抽取之间的这种关联仍然存在.
结论:
- 报告患有青素过敏的孕妇经常接受用于GBS预防的替代抗生素.
- 用于GBS预防的替代抗生素的使用与新生儿产后血液抽取的频率增加有关.
- 母亲选择用于GBS预防的抗生素可以影响新生儿护理,特别是需要更多的实验室调查.
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