三甘油-葡萄糖指数轨迹与大脑动脉动脉样硬化进展之间的关联
Haixu Yu1, Liyuan Tao2, Yan-Guang Li1
1NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Key Laboratory of Molecular Cardiovascular Science, Beijing Key Laboratory of Cardiovascular Receptors Research, Department of Cardiology, Institute of Vascular Medicine, Ministry of Education, Peking University Third Hospital, 100191, Beijing, China.
Cardiovascular diabetology
|May 30, 2023
概括
较高的甘油三糖 (TyG) 指数水平和不断增加的TyG指数轨迹与动脉样硬化进展有关. 这突出了TyG指数.
科学领域:
- 心脏病学 心脏病学
- 代谢健康 代谢健康
- 血管生物学 血管生物学
背景情况:
- 甘油三糖指数 (TyG) 是一种被公认的胰岛素抵抗心脏代谢生物标志物.
- TyG指数与心血管疾病 (CVD) 的发展和预后有关.
- 泰格指数轨迹与动脉样硬化 (CAS) 进展之间的关系仍未得到充分研究.
研究的目的:
- 调查TyG指数和CAS进展的基线和长期轨迹之间的潜在关联.
- 根据TyG指数模式,识别高风险CAS进展的个体.
主要方法:
- 一项纵向前性队列研究,从2011年1月到2020年12月,涉及10,380名成年人.
- TyG指数计算为ln (禁食甘油三 [mg/dL] × 禁食葡萄糖 [mg/dL]/2).
- 隐性类轨迹建模用于分析TyG指数模式; 进行了Cox比例危险分析.
主要成果:
- 基线TyG指数的1-SD增加与CAS进展的7%更高风险相关 (HR=1.067).
- 中等稳定TyG指数轨迹组的参与者显示,CAS进展的风险增加了1.139倍 (HR=1.139).
- 高增长的TyG指数轨迹也与CAS进展相关 (HR=1.206).
结论:
- 较高的基线和中等稳定的TyG指数轨迹与CAS进展有显著的关联.
- 长期TyG指数轨迹可以帮助识别患有CAS进展风险较高的个体.
- 这些发现建议针对高风险个体制定有针对性的预防和治疗策略.
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