运动和表观遗传年龄在老年人与骨髓性恶性瘤
Kah Poh Loh1,2, Chandrika Sanapala3, Marielle Jensen-Battaglia4
1James P. Wilmot Cancer Institute, Rochester, NY, USA. kahpoh_loh@urmc.rochester.edu.
European journal of medical research
|May 30, 2023
概括
移动健康炼干预措施对患有骨髓性恶性瘤的老年人有希望. 减少加速DNA甲基化年龄 (DNAm年龄) 与8-12周计划后改善的身体功能相关.
科学领域:
- 老年学是指老年学的学科.
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 癌症研究 癌症研究
背景情况:
- 患有骨髓性恶性瘤的老年人面临治疗毒性.
- 加快DNA甲基化 (DNAm) 年龄可能预测风险,并受到癌症治疗的影响.
- 运动干预措施显示出在这些患者中减轻损伤的潜力,但对DNAm年龄的影响还未得到充分研究.
研究的目的:
- 探索加速DNAm年龄与基线物理,心理和认知功能之间的关联.
- 为了评估DNAm年龄在移动健康炼干预后的变化.
- 研究加速DNAm年龄变化与功能结果变化之间的关系.
主要方法:
- 一项试点研究涉及老年患有骨髓性恶性瘤的患者接受化疗.
- 一个8-12周的移动健康 (mHealth) 运动干预 (EXCAP) 与移动应用程序相结合.
- 在基线和干预后评估身体,心理和认知功能以及DNAm年龄.
主要成果:
- 加快的灰色年龄,PhenoAge和DunedinPACE在干预后保持稳定.
- 加快的GrimAge,PhenoAge和DunedinPACE的减少与改善的6分钟步行测试距离和握力相关.
- 基线DunedinPACE显示与握力降低的相关性.
结论:
- 在接受mHealth运动的老年人中,GrimAge和PhenoAge在干预后稳定.
- 加速DNAm年龄标记物的减少与增强的体力表现有关.
- 未来的试验应该考虑DNAm年龄作为癌症患者运动干预的生物标志物.
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