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Quantification of Atherosclerosis in Mice
Published on: June 12, 2019
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卡伯内特沙维尼昂干红葡萄酒通过调节炎症和内皮功能,激活AMPK酸化和调节肠道微生物群来改善小鼠的动脉样硬化
Xinlong Cheng1, Xue Han2, Liangfu Zhou1
1Department of Nutrition and Food Safety, College of Food Science and Technology, Hebei Agricultural University, Baoding 071001, PR China.
Food research international (Ottawa, Ont.)
|May 31, 2023
概括
干红葡萄酒富含多,可以保护心血管疾病. 卡伯内特索维尼翁干红葡萄酒 (CSDRW) 通过改善脂质代谢和肠道微生物群,被证明可以减少小鼠的动脉样硬化.
科学领域:
- 心血管研究研究心血管研究
- 营养科学 营养科学
- 代谢学 代谢学 代谢学
背景情况:
- 心血管疾病 (CVD) 构成了全球健康的重大负担.
- 干红酒 (DRW) 中的抗氧化多被假设为提供心脏保护益处.
- 动脉样硬化 (AS) 是心血管疾病的主要驱动因素,其特点是脂质积累和炎症.
研究的目的:
- 为了研究卡伯内特索维尼翁干红葡萄酒 (CSDRW) 的抗动脉样硬化作用.
- 在动脉样硬化小鼠模型中阐明CSDRW对脂质代谢和肠道微生物群的影响的分子机制.
主要方法:
- 使用了动脉样硬化的小鼠模型 (ApoE-/-小鼠).
- 口服CSDRW并评估其对动脉样硬化病变大小和脂质配置文件的影响.
- 采用了代谢分析 (LC-MS/MS) 和分子技术 (例如AMPK,PPARγ-LXR-α-ABCA1通路分析).
- 分析了肠道微生物群的组成.
主要成果:
- 在ApoE-/-小鼠中,CSDRW显著降低了动脉硬性病变的大小和缓解了超脂血症.
- 通过AMPK激活,CSDRW改善了肝脏脂质的积累,并通过PPARγ-LXR-α-ABCA1通路促进了脂质代谢.
- CSDRW增加了有益的肠道细菌的丰富性,包括Bacteroidetes,Verrucomicrobiota和Akkermansiaceae.
- 在CSDRW中确定了各种多 (黄醇,酸,黄醇,白醇) 负责观察到的影响.
结论:
- 在小鼠模型中,CSDRW表现出显著的抗动脉样硬化特性.
- 这些有益的效果是通过改善脂质代谢,减少炎症,增强内皮功能和调节肠道微生物群来调节的.
- 在CSDRW中含有的多是治疗动脉样硬化和心血管疾病的潜在治疗策略.
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