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含有中链甘油三糖的性饮食可以减少REM睡眠时间,但不会显著影响小鼠的昼夜表型
Haotong Zhuang1, Yuri Fujikura2, Naoki Ohkura3
1Healthy Food Science Research Group, Cellular and Molecular Biotechnology Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki, Japan; Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba, Japan.
Food research international (Ottawa, Ont.)
|May 31, 2023
概括
中链甘油三基因饮食 (MCT-KD) 诱导了无饥饿的症,对昼夜节律的影响很小,但减少了小鼠的REM睡眠时间.
科学领域:
- 营养科学 营养科学
- 时间生物学 时间生物学
- 代谢研究研究 代谢研究
背景情况:
- 性饮食 (KDs) 影响昼夜节律,但区分生成与饥饿的影响是具有挑战性的.
- 中链甘油三酸 (MCTs) 可以提高水平而不会引起碳水化合物饥饿.
研究的目的:
- 研究含有MCT的性饮食 (MCT-KD) 对昼夜节律和睡眠调节的影响.
- 为了确定症本身是否独立于饥饿,影响这些生理过程.
主要方法:
- 两周内,小鼠接受了对照饮食 (CTRL) 或MCT-KD.
- 测量血液β-基酸盐,体重,血糖,活动节奏,体温,时钟基因表达和睡眠结构.
主要成果:
- 与CTRL相比,MCT-KD显著增加了血水平 (至~2mM),而没有改变体重或葡萄糖水平.
- 活动的循环节律和体温基本上不受影响,尽管活动略有减少.
- 核心时钟基因表达在各种组织中保持相似,肝脏Per2和脂肪Per1的幅度略有变化.
- MCT-KD减少了快速眼动 (REM) 睡眠时间,但没有影响非REM睡眠或清醒时间.
结论:
- 体对核心昼夜系统的影响有限.
- MCT-KD可能会轻微降低运动运动活动和REM睡眠持续时间.
- 这项研究区分了症与饥饿对昼夜调节和睡眠的影响.
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