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基于Venetoclax的救援疗法用于复发/耐药急性淋巴细胞白血病的成年患者
Jonathan Canaani1, Avraham Frisch2, Daniel A Pollyea3
1Hematology Division, Chaim Sheba Medical Center, Faculty of Medicine, Tel Aviv University, Tel Hashomer, Israel.
European journal of haematology
|May 31, 2023
概括
威尼托克拉克斯的组合疗法在复发性/耐药性急性淋巴细胞白血病 (ALL) 中显示出有效性. 无论是venetoclax-化疗还是venetoclax-navitoclax疗法,在ALL患者中都实现了良好的反应率,并具有可控的毒性.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
背景情况:
- BCL-2家族蛋白质的失调与急性淋巴细胞白血病 (ALL) 有关.
- 在ALL中,白血病克隆通常会对特定的BCL-2家族成员产生依赖.
- 准BCL-2家族蛋白质为ALL提供了一个潜在的治疗策略.
研究的目的:
- 评估基于venetoclax的组合药物的疗效和安全性,用于复发性/耐药性 (r/r) B或T ALL的患者.
- 评估两种不同的venetoclax组合疗法:venetoclax与化疗和venetoclax与navitoclax,vincristine和asparaginase.
主要方法:
- 一项多中心回顾性队列研究包括17名患有r/r B或T ALL的患者.
- 9名患者接受了venetoclax与化疗相结合.
- 13名患者接受了与纳维托克拉克斯,温克里斯和阿斯巴拉金酶联合使用的venetoclax;五名患者之前曾接触过venetoclax.
主要成果:
- 总体响应率 (ORR) 为venetoclax-化疗的55%,为venetoclax-navitoclax组合的46%.
- 在这两组中,大多数受试者都接受了异构骨髓移植.
- 感染性并发症和肝毒性是使用venetoclax-navitoclax疗法的最常见不良事件.
结论:
- 基于Venetoclax的化疗在治疗复发性/耐药性ALL时显示出潜在的疗效.
- 韦尼托克拉克斯与纳维托克拉克斯的组合也显示出希望,尽管具有显著的传染性和肝毒性.
- 这些发现支持对r/rALL中含有venetoclax的疗法进行调查.
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