之前患有COVID-19感染的症状患者的冠状动脉微血管健康:更新的分析
Ahmed Ibrahim Ahmed1, Mahmoud Al Rifai1, Fares Alahdab1
1Houston Methodist DeBakey Heart & Vascular Center, 6565 Fannin St, Houston, TX 77030, USA.
European heart journal. Cardiovascular Imaging
|May 31, 2023
概括
之前的COVID-19感染显著增加了冠状动脉微血管系统受损的风险,特别是在严重的疾病中. 这种效应在各种SARS-CoV-2变种感染后持续长达一年.
科学领域:
- 心脏病学 心脏病学
- 传染性疾病 传染性疾病
- 血管生物学 血管生物学
背景情况:
- 内皮功能障碍是严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 感染的已知并发症.
- 了解COVID-19对冠状动脉微血管的长期影响对于患者管理至关重要.
研究的目的:
- 为了研究以前的COVID-19对冠状动脉微血管结构的影响.
- 为了分析这些影响,考虑感染以来的时间,疾病严重程度,SARS-CoV-2变种和患者亚组 (糖尿病,没有已知的冠状动脉疾病).
主要方法:
- 用正子发射断层扫描 (PET) 图像来评估前COVID-19 (病例) 患者的心肌流量储量 (MFR),并匹配没有感染的对照.
- MFR被计算为压力与心肌静止血流的比率.
- 比较的重点是受损MFR (MFR<2) 的几率和患病率.
主要成果:
- 以前患有COVID-19的患者显示MFR受损的几率明显更高 (调整后的几率比率为3.1).
- 不同的SARS-CoV-2变种和感染后长达一年的MFR发病率差异相似.
- 然而,随着初始COVID-19感染的严重程度,受损的MFR患病率增加.
结论:
- 之前的COVID-19感染与冠状动脉微血管系统受损独立相关.
- COVID-19疾病的严重程度是影响微血管功能障碍程度的重要因素.
- 在COVID-19后的患者的长期随访中,应考虑冠状动脉微血管功能.
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