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Updated: Jul 28, 2025

Isolation of Pulmonary Artery Smooth Muscle Cells from Neonatal Mice
08:02

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Published on: October 19, 2013

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诺奇3/Hes5诱导血管功能障碍在低氧诱导的肺高血压通过ER压力和Redox敏感途径

Hannah E Morris1, Karla B Neves1, Margaret Nilsen2

  • 1Institute of Cardiovascular and Medical Sciences, University of Glasgow, United Kingdom (H.E.M., K.B.N., A.C.M., R.M.T.).

Hypertension (Dallas, Tex. : 1979)
|May 31, 2023
PubMed
概括

功能增益的Notch3 (神经源基位突破同源蛋白3) 突变通过增加氧化和ER压力,以及ROCK信号,加剧肺高血压 (PH). 这项研究揭示了PH病变发生过程中一种新的Notch3/Hes5-redox途径.

关键词:
信号传递的.细胞内膜网膜的内oplasmic网膜.缺氧 缺氧是指缺氧的情况.肺高血压是一种肺高血压.有活性氧物种的反应性氧物种.

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