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基于大脑多重自我调节模型的增强外部对冲动治疗计划,用于大脑缺血性中风

Bao Li¹, Youjun Liu¹, Jincheng Liu¹

¹Department of Biomedical Engineering, Faculty of Environment and Life, Beijing University of Technology, Beijing, China.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

|May 31, 2023

概括

一个新的数学模型模拟了脑血流,以增强中风患者的外部对冲动 (EECP). 它表明,较长的EECP持续时间可能有利于严重的狭窄,而中度的狭窄需要谨慎避免血管损伤.

科学领域:

生物医学工程生物医学工程
计算流体动力学的流体动力学.
脑血管生理学脑血管生理学

背景情况:

脑缺血性中风治疗的疗效,就像增强的外部对冲动 (EECP),是不确定的,因为复杂的脑自调节和变化的狭窄严重程度.
现有的模型往往不能完全捕捉狭窄症严重程度和对EECP的血液动力学反应之间的相互作用.

研究的目的:

开发和验证脑多自调节 (MR) 数学模型,以计算狭窄症的严重程度.
评估不同压缩水平的脑动脉上不同EECP加压持续时间的血液动力学影响和疗效.

主要方法:

开发一个脑MRI数学模型,结合神经性,血管光滑肌反射和剪切应力机制.
对大脑自我调节效率的临床测量进行模型验证.
将MR模型应用于脑动脉的0D/3D多尺度血液动力学模型,以模拟EECP效应.

主要成果:

中度狭窄 (50-60%) 与长时间的EECP显示过度的墙壁剪切应力 (>7Pa) 远距离,风险内皮损伤.
严重的狭窄 (70-80%) 在长时间的EECP中没有表现出血动力学风险,这表明延长持续时间是可行的.
该MR模型准确地模拟了脑血流和血液动力学指标.

结论:

开发的MR模型为在临床环境中模拟大脑血液动力学提供了有价值的工具.
应根据个体脑狭窄症的严重程度量身定制EECP治疗参数,特别是加压的持续时间.
这些发现强调了需要个性化的EECP协议,以优化中风患者的疗效和降低风险.

关键词:

大脑的多重自我调节.大脑的血液流动.大脑缺血性中风脑中风增强了外部对冲的作用.血液动力学血液动力学

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