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在7特斯拉时使用VASO对人类区域MT+对运动轴刺激的柱状功能组织进行成像

Alessandra Pizzuti^1,2, Laurentius Renzo Huber¹, Omer Faruk Gulban^1,2

¹Department of Cognitive Neuroscience, Faculty of Psychology and Neuroscience, Maastricht University, The Netherlands.

Cerebral cortex (New York, N.Y. : 1991)

|May 31, 2023

概括

研究人员使用超高场fMRI量化了人体运动敏感视觉皮层 (hMT+) 的中镜组织. 与BOLD相比,对大脑血液体积敏感的fMRI显示了检测运动轴柱的更高的特异性,为大脑结构提供了新的见解.

科学领域:

神经成像是一种神经成像.
系统神经科学系统神经科学
人类大脑绘制地图

背景情况:

在动物MT中存在方向选择性神经元的微观皮质柱.
人类同类区域 (hMT+) 中的中镜柱状组织在量上仍未得到验证.
以前的研究表明,对运动刺激的反应是可重现的,但缺乏明确的柱状证据.

研究的目的:

量化研究人类MT (hMT+) 的中镜柱状功能组织.
为了比较脑血液体积 (CBV) 敏感的fMRI (VASO) 与检测这些列的BOLD对比的有效性.
开发和应用用于定量列检测和分析的新型算法.

主要方法:

使用了7特斯拉超高场fMRI,具有亚毫米分辨率和高微血管特异性.
采用切片选择性板式倒置 (SS-SI) -VASO序列来获取BOLD和CBV敏感 (VASO) 数据.
开发了一种新的搜索灯算法,用于在整个3D hMT+卷中进行定量列检测.

主要成果:

创建了3D hMT+卷的第一个定量柱状图.
与BOLD相比,对于CBV敏感的VASO对比,运动轴皮质柱的特异性更高.
对voxel的敏感性和特异性指标提供了关于减轻静脉排水效应的见解.

结论:

CBV-VASO fMRI与voxel-wise指标相结合,提供了一种强有力的方法来量化hMT+中介镜组织.
开发的方法提供了一个有前途的途径来研究人类大脑中镜组织.
这种方法可以将其推广到人类大脑的其他区域,用于类似的中视镜研究问题.

关键词:

7 特斯拉特斯拉是什么意思在V5-hMT+中使用.列列是指列中的列.功能磁力共振成像 (fMRI) 是一种在 mesoscale 中的尺度.

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