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Updated: Jul 28, 2025

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MUS81的酸化状态是BRCA2缺乏细胞中Olaparib敏感性的修饰剂

Francesca Blandino1, Eva Malacaria1, Carolina Figlioli1

  • 1Mechanisms, Biomarkers and Models Unit, Department of Environment and Health, Istituto Superiore di Sanità - Viale Regina Elena 299, 00161 Rome, Italy.

Nucleic acids research
|May 31, 2023
PubMed
概括

线粒分裂中MUS81功能丧失会影响BRCA2缺陷细胞的活力,但不会影响PARPi敏感性. 然而,构成性MUS81活动通过割裂停滞的复制叉来赋予PARPi抗性.

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