同时训练和辅酶Q10对多发性硬化症患者的神经营养因子和身体功能的影响:试点研究
Amir Hossein Haghighi1, Amin Ahmadi2, Antonio Carotenuto3
1Department of Exercise Physiology, Faculty of Sport Sciences, Hakim Sabzevari University, Sabzevar. ah.haghighi@hsu.ac.ir.
European journal of translational myology
|May 31, 2023
概括
同时训练 (CT) 在多发性硬化症 (MS) 患者中显著改善功能能力. 辅酶Q10 (CoQ10) 补充剂没有增强这些益处,这表明CT是MS身体改善的关键.
科学领域:
- 神经学 神经学
- 运动生理学 运动生理学
- 营养科学 营养科学
背景情况:
- 多发性硬化症 (MS) 是一种慢性神经疾病,影响功能能力.
- 同时训练 (CT) 和辅酶Q10 (CoQ10) 是对MS的潜在干预措施.
- 调查CT和CoQ10对MS功能能力和神经营养因子的联合影响至关重要.
研究的目的:
- 为了确定一个为期8周的并发训练 (CT) 计划,与或没有辅助辅酶Q10 (CoQ10) 补充,对多发性硬化症 (MS) 患者的功能能力的影响.
- 评估CT和CoQ10对MS患者脑衍生神经营养因子 (BDNF) 和神经生长因子 (NGF) 的血清水平的影响.
- 为了比较单独使用CT,单独使用CoQ10及其与安慰剂的组合在MS中改善身体功能和神经变标记物的疗效.
主要方法:
- 一个随机的安慰剂受控试验,涉及28名MS患者,分为四组:CT+安慰剂,CT+CoQ10,CoQ10和安慰剂.
- 同步训练 (CT) 每周包括两次抵抗和一次有氧训练,持续8周.
- 辅酶Q10 (CoQ10) 每天服用200毫克. 干预前和后测量了功能能力 (TUG,6MW,强度测试) 和血清BDNF/NGF水平.
主要成果:
- 与CoQ10和安慰剂组相比,CT+安慰剂和CT+CoQ10组在所有功能能力测试 (TUG,6MW,强度) 中均显著改善.
- 与CT+CoQ10组相比,CT+安慰剂组在Timed Up and Go (TUG) 测试中表现出显著更大的改善.
- 在干预后的四组中没有观察到血清BDNF或NGF水平的显著差异.
结论:
- 同时训练 (CT) 有效地提高了多发性硬化症 (MS) 患者的身体能力和功能能力.
- 辅酶Q10 (CoQ10) 补充似乎没有为CT提供额外的好处,改善MS中的功能能力或神经营养因素.
- 对于MS患者来说,CT应该被推用于改善功能能力,但这些发现不支持补充CoQ10.
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