智能交付平台使用核心纳米纤维,用于在伤口愈合过程中顺序释放药物
Baljinder Singh1, Junkee Kim1, Nutan Shukla1
1Department of Convergence Science, Sahmyook University, Seoul 01795, South Korea.
ACS applied bio materials
|May 31, 2023
概括
这项研究介绍了一个智能纳米纤维平台,用于加速伤口愈合. 它使用具有双重药物释放的核心外结构,由光诱导的热量触发,以控制治疗输送.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术纳米技术
- 再生医学是一种再生医学.
背景情况:
- 电纳米纤维由于其仿生结构,为伤口愈合提供了多功能矩阵.
- 控制药物输送对于优化伤口愈合阶段至关重要.
- 现有的平台缺乏动态药物释放的可编程性.
研究的目的:
- 开发和评估一个核心纳米纤维平台,用于控制,双药物输送,以加速伤口愈合.
- 为了研究光触发,局部加热从纳米纤维核心可编程药物释放.
- 评估这个平台对先进的伤口护理应用的潜力.
主要方法:
- 核心外纳米纤维的制造,在外中封装药物 (聚-l-乳酸) 和核心中的金纳米棒 (聚 ((N-异烯胺)).
- 在室温和近红外光照射下药物释放特征的描述.
- 对光感应加热和随后的聚合物膨胀/收缩进行控制释放调制的评估.
主要成果:
- 贝层证明了在室温下初始的药物释放.
- 嵌入的金纳米棒在近红外光照射时产生局部热量.
- 热响应的核心使可编程药物释放成为可能,展示了一个智能输送系统.
结论:
- 开发的核心纳米纤维平台为伤口愈合提供了一种多功能和可控的方法.
- 这项技术促进了针对性和安全的药物输送,可适应不同愈合阶段.
- 该平台有可能治疗除了伤口护理之外的各种局部疾病.
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