美国成人患有和没有糖尿病的亚临床心血管疾病
Michael Fang1, Dan Wang1, Olive Tang1
1Johns Hopkins University Baltimore MD.
Journal of the American Heart Association
|May 31, 2023
概括
亚临床心血管疾病 (CVD) 影响了近三分之一的美国成人糖尿病,显著增加死亡风险. 心脏生物标志物测试可以帮助评估和监测糖尿病患者的风险.
科学领域:
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
背景情况:
- 亚临床心血管疾病 (CVD) 越来越令人担忧,特别是在糖尿病的背景下.
- 在美国一般人口中,使用心脏生物标志物评估亚临床心血管疾病的负担和预后影响,重点是糖尿病患者,这一点至关重要.
研究的目的:
- 通过心脏生物标志物识别的亚临床心血管疾病的患病率和预后价值的特征,在美国有和没有糖尿病的成人中.
- 检查心脏生物标志物升高与糖尿病患者死亡率之间的关联.
主要方法:
- 使用了来自国家健康和营养检查调查 (1999-2004) 的血清样本来测量高灵敏度的心脏素T (hs-cTnT) 和N-终端亲B型尿素 (NT-proBNP).
- 估计了糖尿病和没有糖尿病的成年人中生物标志物升高的患病率,并分析了它们与所有原因和心血管疾病死亡率的关联,经过对混因子进行调整后.
主要成果:
- 在患有糖尿病的成年人中,亚临床心血管疾病的患病率大约是患有糖尿病的成年人 (33.4%) 和没有糖尿病的成年人 (16.1%) 的两倍.
- 在糖尿病患者中,hs-cTnT的升高更为常见,特别是那些糖尿病持续时间较长,血糖控制较差的人.
- 在糖尿病患者中,高hs-cTnT和NT-proBNP独立地与增加全因和心血管疾病死亡率有关.
结论:
- 亚临床心血管疾病影响了美国大约三分之一的糖尿病成年人,并与大量的死亡风险有关.
- 对hs-cTnT和NT-proBNP等心脏生物标志物的常规检测可能有助于评估和监测糖尿病患者心血管风险.
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