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晚期发病的新生儿感染和细菌的多重耐药性
Carmen Sulinete Suliano da Costa Lima1, Hermano Alexandre Rocha Lima2,3, Cláudia Sofia de Assunção Gonçalves E Silva1
1Universidade Fernando Pessoa, Porto, Portugal.
概括
多药耐药 (MDR) 细菌在新生儿重症监护室 (NICU) 中越来越令人担忧,导致潜在的治疗失败. 持续的预防方案对于对抗这些高度病态和致命的感染至关重要.
科学领域:
- 新生儿科学 新生儿科学
- 传染性疾病 传染性疾病
- 微生物学 微生物学
背景情况:
- 晚发性医疗相关感染 (HAI) 在新生儿重症监护室 (NICU) 构成重大威胁.
- 了解细菌耐药性模式对于在脆弱的新生儿中有效治疗和感染控制至关重要.
研究的目的:
- 描述细菌病原体及其在实验室确认的NICU中晚发性HAI中的抗菌敏感性概况.
- 评估这些感染中多药性耐药性 (MDR),扩展性耐药性 (XDR) 和泛药性耐药性 (PDR) 的流行率.
主要方法:
- 从2013年1月到2017年12月进行了一项横截面研究.
- 分析了细菌类型,抗微生物敏感性和耐药性分类 (MDR,XDR,PDR).
- 数据使用比例和频率分布来呈现.
主要成果:
- 在427个晚发性HAI中,47个 (11.0%) 确诊为细菌感染,其中7个 (14.9%) 是由MDR细菌引起的.
- 格拉姆阴性细菌 (55.3%) 对安培 (81.2%) 和塞费皮姆 (33.1%) 呈现出高耐药性.
- 格拉姆阳性细菌对青素 (80.0%) 和牛素具有很高的耐药性,但万科米辛仍然具有很高的效果 (97.5%的敏感性).
结论:
- 该研究证实了MDR菌株在NICU中出现的情况,强调了治疗失败的风险.
- 需要持续的预防策略来最大限度地降低高发病率细菌的污染风险.
- 在NICU环境中,有效的抗菌药物管理和感染控制至关重要.
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