相关实验视频
Updated: Jul 28, 2025
08:40
Chronic Salmonella Infection Induced Intestinal Fibrosis
Published on: September 22, 2019
7.2K
炎症性肠病患者恶性瘤和严重感染的危险因素:回顾性分析
Daniel Tassone1,2, Chamara Basnayake1,2, Emily Wright1,2
1Department of Gastroenterology, St Vincent's Hospital Melbourne, Melbourne, Victoria, Australia.
Internal medicine journal
|May 31, 2023
概括
患有炎症性肠病 (IBD) 的患者面临更高的癌症和感染风险. 较长的IBD持续时间和结肠直肠性克罗恩病增加了恶性瘤的风险,而硫氨酸和抗TNF疗法并没有提高这些风险.
科学领域:
- 胃肠病学和肝病学
- 在瘤学瘤学.
- 传染性疾病 传染性疾病
背景情况:
- 与普通人群相比,患有炎症性肠病 (IBD) 的患者患恶性瘤和感染的风险较高.
- 在IBD队列中确定特定的风险因素对于主动管理和改善患者结果至关重要.
研究的目的:
- 为了确定患有炎症性肠道疾病的患者队列中恶性瘤和严重感染的危险因素.
- 评估免疫抑制剂 (thiopurines和抗瘤亡因子-alpha) 暴露与不良事件的发生之间的关联.
主要方法:
- 在第三级推中心对549名IBD患者的人口和临床数据的回顾性分析.
- 检查医疗记录的不良事件,包括恶性瘤和医院所需的感染.
- 后勤回归分析以确定不良事件的风险因素.
主要成果:
- 在队列中发现了48种恶性瘤和92种严重感染.
- 增长的IBD持续时间 (OR=1.08) 和结肠直肠类克朗病 (OR=4.96) 与更高的恶性瘤风险有关.
- 与非暴露相比,提奥普林和抗瘤坏死因子α暴露都与恶性瘤或严重感染风险的增加无关.
结论:
- 结肠杆菌性克罗恩病和更长的IBD持续时间是恶性瘤的重要危险因素.
- 提奥普林和抗瘤坏死因子-阿尔法疗法与本IBD队列中恶性瘤或严重感染的风险增加无关.
- 这些发现有助于风险分层,并为IBD患者的治疗决策提供信息.
相关概念视频
01:30Inflammatory Bowel Disease II: Crohn's Disease
306
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
306
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
227
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
227
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
365
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
365
01:17Chronic Bowel Disorders: Introduction
493
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
493
01:26Factors Affecting the Risk of Infection
12.1K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
12.1K
01:21Inflammatory Bowel Disease V: Surgical Management
174
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
Here are some common surgical interventions for IBD:
174