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曼吉费林和牛素通过抑制NF-κB信号传递来改善MSRV感染
Caijiao Dai1,2, Li Yu3, Zhiwen Wang1,2
1Department of Aquatic Animal Medicine, College of Fisheries, Huazhong Agricultural University, Wuhan, People's Republic of China.
Microbiology spectrum
|May 31, 2023
概括
这项研究表明,炎症和氧化应激是M. salmoides rhabdovirus (MSRV) 感染的关键因素. 曼吉费林和氨酸通过通过NF-κB信号通路抑制MSRV,显示出抗病毒潜力.
科学领域:
- 水产养殖病毒学
- 鱼类免疫学 鱼类免疫学
- 开发抗病毒药物 开发抗病毒药物
背景情况:
- 新出现的病毒构成全球威胁,但抗病毒治疗仍然不发达,特别是在水产养殖中.
- 尽管有各种病毒病原体影响鱼类生产,但没有批准的抗病毒药物用于水产养殖.
- 水产养殖对全球粮食安全,健康和减少贫困至关重要,使得鱼类疾病管理至关重要.
研究的目的:
- 为了研究一种新型细胞系中微型类沙尔莫病毒 (MSRV) 的病理生理学.
- 识别针对MSRV的潜在抗病毒化合物.
- 阐明针对MSRV的抗病毒作用机制.
主要方法:
- 从Micropterus salmoides大脑 (MSBr) 开发了一种新的上皮细胞系.
- 利用转录组分析和生物化学测试来研究MSRV诱导的病理生理学.
- 评估了mangiferin和taurine在抑制MSRV复制和它们对NF-κB信号传递的影响中的有效性.
主要成果:
- 在MSBr细胞中,MSRV感染诱导了炎症和氧化应激,由高细胞因子和氧化损伤生物标志物证明.
- 曼吉费林和氨酸显著抑制了MSRV复制,EC50值分别为6.77微克/毫升和8.02微克/毫升.
- 曼吉费林和氨酸抑制了MSRV诱导的NF-κB信号激活,表明它们的抗病毒机制.
结论:
- 炎症和氧化应激是MSRV病理生理学的核心.
- 曼吉费林和氨酸通过抑制NF-κB信号传递,对MSRV表现出显著的抗病毒活性.
- 针对炎症反应为开发用于水产养殖的广泛抗病毒药物提供了一个有希望的策略.
关键词:
麦克罗普特鲁斯·萨尔莫伊德斯 (Micropterus salmoides) 是一个很小的动物.在NF-κB信号传输中.这是一种炎症炎症炎症炎症.在Mangiferin中进行调试.氧化应激是一种氧化应激.taurine taurine taurine taurine taurine taurine taurine taurine taurine taurine taurine taurine taurine taurine taurine taurine taurine taurine taurine taurine taurine taurine taurine taurine taurine taurine taurine taurine taurine taurine taurine taurine taurine taurine taurine taurine taurine taurine taurine taurine taurine taurine taurine taurine taurine taurine taurine taurine taurine taurine taurine taurine taurine taurine taurine taurine taurine taurine taurine 是一种类型的蛋白质,其含量很大.
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