描述参与艾滋病毒护理级联:一项方法学研究
Diya Jhuti1,2, Gohar Zakaryan1, Hussein El-Kechen3
1Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.
HIV/AIDS (Auckland, N.Z.)
|May 31, 2023
概括
定义对艾滋病毒护理的参与对于实现不可检测的病毒载荷至关重要. 这项研究在各个试验中发现了不同的定义,突出了提高艾滋病毒护理级联研究的标准化方法的需要.
科学领域:
- 公共卫生 公共卫生
- 传染性疾病 传染性疾病
- 临床试验 临床试验
背景情况:
- 参与艾滋病毒护理级联对于艾滋病毒感染者 (PLWH) 实现无法检测的病毒载量至关重要.
- 对参与的不一致的定义在研究中产生异质性,使得难以准确评估参与和收益.
研究的目的:
- 描述艾滋病毒临床试验中使用的各种参与定义.
- 突出艾滋病毒护理级联中的参与定义的多样性.
主要方法:
- 在CASCADE数据库中对研究进行了系统审查 (298个HIV护理级联临床试验).
- 将参与列为结果的研究被选择并根据其对参与的定义进行分析.
主要成果:
- 在13项符合条件的研究中,有5项缺乏对参与的明确定义.
- 通常使用的定义包括预约遵守 (n=6),时间规范 (n=5) 和干预遵守 (n=5).
- 其他定义包括实验室检测 (n=2),抗逆转录病毒治疗的坚持 (n=2) 和相互作用的质量 (n=1).
结论:
- 在艾滋病毒护理级联研究中,参与的定义和测量方式存在显著的多样性.
- 建议就参与度的标准化定义和测量达成共识,以提高数据的可比性和聚合性.
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