癌症中的卡德林和丁:连接癌症途径和瘤微环境
Wan-Hsin Lin1, Lisa M Cooper1, Panos Z Anastasiadis1
1Department of Cancer Biology, Mayo Clinic, Jacksonville, FL, United States.
Frontiers in cell and developmental biology
|May 31, 2023
概括
卡德林-丁复合体调节细胞粘附和组织稳定性. 它们的调节失调通过改变瘤信号通路和瘤微环境来影响癌症,突出了关键的交叉通话.
科学领域:
- 细胞生物学 细胞生物学
- 癌症生物学 癌症生物学
- 分子瘤学分子瘤学
背景情况:
- 卡德林-卡特宁复合体对于细胞-细胞粘附和组织恒温是必不可少的.
- 这些复合体的失调与通过瘤信号和瘤微环境改变的癌症发展有关.
- 多组学的进步揭示了复杂的信号事件,需要更深入地了解素-素与瘤途径的相互作用.
研究的目的:
- 审查古典干素和相关的干素的生物功能.
- 描述卡德林-卡特宁失调如何影响主要癌症途径.
- 讨论在癌症中卡德林复合体和细胞信号传递之间的反机制.
主要方法:
- 文献综述,重点关注卡德林-丁复合体和癌症信号传递.
- 在包括Hippo-Yap/Taz,受体氨酸激酶,Wnt,Notch,刺和TGFβ.在内的途径中的交叉分析.
- 在机械传导和免疫瘤微环境中探索卡德林的作用.
主要成果:
- 卡德林-丁复合体是细胞粘附和组织平衡的核心.
- 这些复合物的失调与通过瘤信号传递和瘤微环境调制与癌症有关.
- 在卡德林复合体和关键癌症相关途径之间存在交叉调节,如Hippo-Yap/Taz,RTK,Wnt,Notch,hedgehog和TGFβ-EMT.
结论:
- 卡德林-卡特宁复合体在癌症的发展和进展中发挥着多方面的作用.
- 了解卡德林复合体和瘤性途径之间的交叉是癌症研究的关键.
- 对卡德林在机械传导和免疫微环境中的作用进行进一步的研究可能会提供新的治疗策略.
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