健康个体的HOMA-IR平均值:伊朗受试者的基于人口的研究
Seyed Mohammad Masoodian1, Abolfazl Omidifar1, Sepideh Moradkhani1
1Department of Biochemistry and Immunochemistry, Massoud Laboratory, Tehran, Iran.
Journal of diabetes and metabolic disorders
|May 31, 2023
概括
在健康的伊朗人中,恒温模式评估估计的胰岛素抵抗 (HOMA-IR) 为2.11±0.99.9. 在所有年龄组中,男性的HOMA-IR显著高于女性,这表明胰岛素耐药性的潜在性别差异.
科学领域:
- 内分泌学 在内分泌学.
- 代谢健康 代谢健康
- 人口健康 人口健康
背景情况:
- 胰岛素抵抗是代谢障碍的一个关键因素.
- 恒温模式评估估计的胰岛素抵抗 (HOMA-IR) 是一个广泛使用的指标.
- 确定HOMA-IR的特定人群参考值对于准确的诊断至关重要.
研究的目的:
- 为了确定健康的伊朗成年人的大量人口样本中的平均HOMA-IR值.
- 分析伊朗人口中不同的人口分组的HOMA-IR值.
- 在伊朗背景下提供HOMA-IR的参考数据.
主要方法:
- 一项基于人口的研究,涉及18至70岁的健康成年人.
- 使用电化学发光法 (Roche Cobas e601/602) 测量了禁食胰岛素水平.
- 在各种子组中计算和分析了HOMA-IR指数.
主要成果:
- 在伊朗健康人群中,HOMA-IR的整体平均值为2.11 ± 0.99 (2.5至97.5百分位数:0.66-4.50).
- 与女性 (2.05 ± 1.0) 相比,男性 (2.35 ± 1.0) 的平均HOMA-IR值更高.
- 在所有年龄小组 (P <0.01) 中,男性与女性相比,在男性中观察到HOMA-IR的统计学上显著增加.
结论:
- 该研究为健康的伊朗人口确定了2.11±0.99的平均HOMA-IR.
- 在HOMA-IR中发现了基于性别的显著差异,男性的HOMA-IR值更高.
- 由于样本大小和观察到的变化,建议对伊朗特定种族的HOMA-IR标准化进行进一步研究.
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