基本金属对胰岛素敏感性和肥胖相关的2型糖尿病发病因子中的fetuin的影响
Anumesh K Pathak1, Vandana Tiwari1, Manish Raj Kulshrestha1
1Department of Biochemistry, Dr. Ram Manohar Lohia Institute of Medical Sciences, Lucknow, 226010 India.
Journal of diabetes and metabolic disorders
|May 31, 2023
概括
像这样的必需金属在2型糖尿病 (T2DM) 和肥胖中起着关键作用. 在T2DM患者中发现了较低的铜,,和铁水平,影响了胰岛素抵抗和敏感性.
科学领域:
- 代谢学 代谢学 代谢学
- 营养科学 营养科学
- 内分泌学 在内分泌学.
背景情况:
- 肥胖和2型糖尿病 (T2DM) 是复杂的代谢障碍.
- 基本金属越来越多地被认为是对代谢健康和疾病发病的作用.
研究的目的:
- 研究患有和没有肥胖和T2DM的个体中必需金属的水平.
- 探索金属含量,Fetuin-A (Fet-A),胰岛素敏感性和胰岛素耐药性之间的联系.
主要方法:
- 这项涉及314名参与者的横截面研究分为四组:糖尿病肥胖者,糖尿病非肥胖者,非糖尿病肥胖者和非糖尿病非肥胖者.
- 评估fetuin-A (Fet-A),胰岛素敏感性 (QUICKI),胰岛素耐药性 (HOMA-IR),禁食葡萄糖和身体质量指数 (BMI).
- 使用感应合等离子体质谱法 (ICP-MS) 量化基本金属.
主要成果:
- 在T2DM患者中,Fet-A水平显著更高,与胰岛素耐药性正相关,与胰岛素敏感性负相关.
- 在糖尿病患者中,铜 (Cu), (Se), (Zn) 和铁 (Fe) 的含量显著降低.
- Se和Zn与Fet-A,胰岛素耐药性和胰岛素敏感性有显著的相关性. (Mn) 在糖尿病肥胖组中显示出显著的相关性. (Mg) 被确定为糖尿病的独立预测因子.
结论:
- (Mg) 在与肥胖相关的T2DM的发病和并发症中发挥着重要作用.
- Fet-A水平的变化,胰岛素敏感性和胰岛素抵抗受糖尿病中必需金属的影响.
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