相关实验视频

Updated: Jul 28, 2025

Author Spotlight: Integrating Tai Chi with Mindfulness Training to Achieve an Effective Mind-Body Exercise

Author Spotlight: Integrating Tai Chi with Mindfulness Training to Achieve an Effective Mind-Body Exercise

Published on: July 14, 2023

在糖尿病神经病变患者中,P300参数与认知功能之间的关联

Sarah Parveen¹, Majumi M Noohu¹

¹Centre for Physiotherapy & Rehabilitation Sciences, Jamia Millia Islamia, New Delhi, India.

Journal of diabetes and metabolic disorders

|May 31, 2023

概括

与事件相关的潜在P300波延迟和振幅与糖尿病外围神经病变 (DPN) 患者的认知功能和双重任务性能有关. 这些发现突出了P300作为DPN认知变化的潜在生物标志物.

科学领域:

神经科学是一个神经科学.
临床医学临床医学
心理学心理学心理学

背景情况:

糖尿病外围神经病变 (DPN) 是2型糖尿病 (T2DM) 的常见并发症.
认知功能障碍越来越多地被认为是DPN患者的重要并发症.
了解DPN认知障碍的神经基础对于开发有针对性的干预措施至关重要.

研究的目的:

研究与事件相关潜力 (ERP) P300特征与DPN患者的认知功能之间的关联.
在这个人群中探索P300措施和双重任务表现之间的关系.

主要方法:

对19名患有DPN的T2DM患者进行了横截面分析.
用糖尿病神经病症症状评分 (DNSS) 和振动感知值 (VPT) 来评估神经病变.
认知功能的评估是使用迷你精神状态检查 (MMSE) 和Trail Making Test-B (TMT-B),以及P300延迟和振幅测量. 双任务成本 (DTC) 是通过时间和行驶 (TUG) 和双任务 (TUG-DT) 的 TUG 测试来计算的.

主要成果:

P300延迟与TMT-B (R=0.31,p=0.01) 和DTC (R=0.22,p=0.04) 呈现出线性关系.
P300振幅也与TMT-B (R=0.13,p=0.04) 和DTC (R=0.67,p=0.001) 有关.
在MMSE得分和P300延迟或振幅之间没有发现显著的关系.

结论:

P300的延迟和幅度与认知功能有关,特别是执行功能和注意力,根据DPN患者的TMT-B和DTC测量.
这些发现表明,P300可能作为DPN认知缺陷的神经生理学标记.

关键词:

糖尿病外围神经病变糖尿病外围神经病变这是一个双重任务.在ERP P300中使用ERP P300.炎症炎症是一种炎症.2型糖尿病是什么? 2型糖尿病是什么?

更多相关视频

Osmotic Minipump Implantation for Increasing Glucose Concentration in Mouse Cerebrospinal Fluid

Osmotic Minipump Implantation for Increasing Glucose Concentration in Mouse Cerebrospinal Fluid

Published on: April 7, 2023

Assessment and Communication for People with Disorders of Consciousness

Assessment and Communication for People with Disorders of Consciousness

Published on: August 1, 2017

相关概念视频

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...

Psychoneuroimmunology: Diabetes and Cancer

Psychoneuroimmunology: Diabetes and Cancer

Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...