优化微波辅助提取来自Eleutherine bulbosa的多代谢物 (Mill.) 的微波辅助提取方法 城市. 城市. 使用响应表面方法的灯泡
Islamudin Ahmad1,2, Angga Cipta Narsa2, M Riki Ramadhani1
1Department of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia.
概括
优化微波辅助提取 (MAE) 有效地从Eleutherine bulbosa灯泡中提取多. 这种方法为使用印尼特有植物的制药应用提供了快速,经济高效的方法.
科学领域:
- 植物化学 植物化学
- 自然产品化学 自然产品化学
- 提取技术 提取技术
背景情况:
- 印度尼西亚特有植物Eleutherine bulbosa灯泡具有重要的药物应用潜力.
- 有效的提取方法对于从E. bulbosa.中分离有价值的二次代谢物至关重要.
- 微波辅助提取 (MAE) 为快速有效的代谢物分离提供了一个有前途的技术.
研究的目的:
- 优化微波辅助提取 (MAE) 条件,从E. bulbosa球泡中提取多.
- 使用响应表面方法 (RSM) 确定最大化总多含量 (TPC) 的最佳参数.
主要方法:
- 使用微波辅助提取 (MAE) 来提取全聚含量 (TPC).
- 使用Box-Behnken设计的响应表面方法 (RSM) 用于优化.
- 通过光谱光度和Folin-Ciocalteu试剂确定了TPC值.
主要成果:
- 最佳MAE条件被确定为60%的乙醇,1:10 g/mL的样品溶剂比率和50%的微波功率10分钟.
- 为TPC建立了一个预测二次回归模型.
- 一个扩大规模的确认测试给出了35.33±2.13毫克的酸等效/g的样本.
结论:
- 优化的MAE方法是有效的,快速和高效的,用于丰富E. bulbosa.的多.
- 开发的方法适用于低成本生产制药成分.
- RSM成功地优化了MAE参数,用于从E. bulbosa.中提取多.
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