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Calorimetry01:19

Calorimetry

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When objects at different temperatures are placed in contact with each other but isolated from everything else, they attain thermal equilibrium. A container that prevents heat transfer in or out is called a calorimeter, and the use of a calorimeter to make measurements is called calorimetry. Generally, these measurements involve heat or specific heat capacity. The term "calorimetry problem" is used for any problem where the specified objects are thermally isolated from their...
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使用差异扫描热量计的莫达芬利-辅助剂兼容性研究.

Derar Omari1, Assayed Sallam2, Hasan Al-Hmoud1

  • 1Department of Pharmaceutical Technology and Pharmaceutics, Faculty of Pharmacy, Yarmouk University, Irbid, Jordan.

Journal of advanced pharmaceutical technology & research
|May 31, 2023
PubMed
概括
此摘要是机器生成的。

通过差异扫描热量计来研究modafinil药物辅助剂的兼容性,发现了与Gelucire 48/16的相互作用. 莫达菲尼尔与酸酸没有显著的相互作用.

关键词:
不同扫描热量计差异扫描热量计.异剂的兼容性 异剂的兼容性莫达菲尼尔 (Modafinil) 的使用方法热学研究热学研究

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科学领域:

  • 制药科学 制药科学
  • 材料科学 材料科学 材料科学

背景情况:

  • 药物辅助剂的兼容性对于药物制品的成功配方至关重要.
  • 热分析技术,包括差异扫描热量计 (DSC),对于评估药物辅助剂相互作用是有价值的.
  • 作为一种促进清醒的药物,莫达菲尼尔 (Modafinil) 需要精心配制,以确保其稳定性和有效性.

研究的目的:

  • 为了评估modafinil与常见的制药辅助剂,酸 (MgSt) 和Gelucire 48/16的兼容性.
  • 在非异热条件下使用DSC. 调查药物辅助剂相互作用.
  • 为了确定modafinil及其与辅助剂的物理混合物的激活能量 (Ea).

主要方法:

  • 使用非异热差扫描热量计 (DSC).
  • 分析了莫达菲尼尔纯物质及其与MgSt和Gelucire 48/16的物理混合物.
  • 用四个加热速率 (5,10,15,20°C/分钟) 来计算激活能量 (Ea).
  • 福里埃变换红外光谱法 (FTIR) 和核磁共振 (NMR) 光谱法用于进一步分析.

主要成果:

  • 发现modafinil-Gelucire 48/16物理混合物的激活能量 (Ea) 增加,这表明药物与辅助剂的相互作用.
  • 在modafinil和酸 (MgSt) 之间没有发现显著的相互作用.
  • 光谱分析 (FTIR,NMR) 支持了与Gelucire 48/16.6相互作用的发现.

结论:

  • 凝露48/16与莫达菲尼尔的相互作用,表明潜在的配方挑战或好处.
  • 在研究的条件下,酸似乎是与莫达菲尼尔兼容的辅助剂.
  • DSC与光谱方法相结合,为在药物开发中评估药物辅助剂兼容性提供了一个强大的方法.