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一般化Q空间MRI揭示了瘤架构的宏观模式in vivo

Erik N Taylor¹, Yao Ding², Leon Lin¹

¹Chemistry and Chemical Biology, Northeastern University, Boston, MA, USA.

Proceedings of the IEEE ... annual Northeast Bioengineering Conference. IEEE Northeast Bioengineering Conference

|May 31, 2023

概括

这项研究引入了一种新的体内MRI方法,用于绘制瘤微观结构和细胞对齐的地图. 这项技术揭示了头癌的独特组织模式,有助于瘤生物学评估.

科学领域:

生物医学成像技术生物医学成像技术
在瘤学瘤学.
医学物理医学物理

背景情况:

目前的瘤分析依赖于切除或活检的组织.
瘤表现出复杂的异质性,需要进行体内宏观检查.
了解瘤微观结构对于有效的治疗策略至关重要.

研究的目的:

开发和验证一种新的体内磁共振成像 (MRI) 方法.
探测瘤的微观结构成分和细胞组织.
评估头癌的宏观组织特征.

主要方法:

利用了具有不同磁场梯度的通用化Q空间MRI.
测量了质子扩散率的voxel尺度概率分布函数.
在体内采用通道图谱绘制多声细胞对齐图.

主要成果:

在头部和部瘤中成功描绘了宏观组织特征.
确定了区域差异,区分一个连贯的外围和一个不连贯的核心.
证明了瘤组织体内微结构分析的可行性.

结论:

这种新的MRI方法提供了一种评估瘤生物学的非侵入性方法.
这种技术有可能预测瘤对治疗和干预措施的反应.
宏观瘤组织提供了超越传统分子表征的宝贵见解.

关键词:

在Q空间成像中使用Q空间成像.瘤组织组织的组织.生物连接性的生物连接性.扩散权重的磁共振成像技术

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Magnetic Resonance Imaging

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Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...